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Peptide Hormone

Search Result - 1

HMRbase accession number	10007
Swiss-prot Accession number	Q9BQD1 (Sequence in FASTA format)
Description	Pro-MCH-like protein 2 (Pro-melanin-concentrating hormone-like protein2).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	N/A
Developmental Stage	Not expressed during brain development.
Similarity	Belongs to the melanin-concentrating hormone family.
Tissue Specificity	Expressed in testis but not in brain
Post translational modification	N/A
Function	N/A
Protein Length	86 Amino acids
Molecular weight	9856
References	1  PubMed abstract 11181993 2  PubMed abstract 8188237 3  PubMed abstract 11070051
Domain Name	Pro-MCH
Hormone Name	Melanin-concentrating hormone-like
Mature Hormone Sequence	DFDTLRCMLGRVYQRCWQV
Position of mature hormone in Pre-Hormone protein	19 Residues from position (68-86)
Receptor	Q99705   Detail in HMRbase    Q969V1    Detail in HMRbase
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 2

HMRbase accession number	10027
Swiss-prot Accession number	P01178 (Sequence in FASTA format)
Description	Oxytocin-neurophysin 1 precursor (OT-NPI) [Contains: Oxytocin(Ocytocin); Neurophysin 1].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the vasopressin/oxytocin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland
Protein Length	125 Amino acids
Molecular weight	12722
References	1  PubMed abstract 3768139 2  PubMed abstract 2991279 3   Grunwald W.C. Jr., Cool D.R.; "Lack of sequence polymorphism in the oxytocin gene of autisticpatients."; Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases. 4  PubMed abstract 11780052 5  PubMed abstract 15489334 6  PubMed abstract 2249637 7  PubMed abstract 4065330 8  PubMed abstract 6574452 9  PubMed abstract 7262323 10  PubMed abstract 13591312
Domain Name	Hormone_5
Hormone Name	Oxytocin
Mature Hormone Sequence	CYIQNCPLG
Position of mature hormone in Pre-Hormone protein	9 Residues from position (20-28)
Receptor	P30559    Detail in HMRbase
Gene ID	5020
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 3

HMRbase accession number	10102
Swiss-prot Accession number	Q14406 (Sequence in FASTA format)
Description	Chorionic somatomammotropin hormone-like 1 precursor (Chorionicsomatomammotropin-like) (Lactogen-like).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the somatotropin/prolactin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation
Protein Length	199 Amino acids
Molecular weight	22649
References	1  PubMed abstract 2744760 2  PubMed abstract 8083227
Domain Name	Hormone_1
Hormone Name	Chorionic somatomammotropin hormone-like 1
Mature Hormone Sequence	VQTVPLSRLFKEAMLQAHRAHQLAIDTYQEFISSWGMDSIPTSSNMEETQQKSNLELLHISLLLIESRLEPVRFLRSTFTNNLVYDTSDSDDYHLLKDLEEGIQMLMGRLEDGSHLTGQTLKQTYSKFDTNSHNHDALLKNYGLLHCFRKDMDKVETFLRMVQCRSVEGSCGF
Position of mature hormone in Pre-Hormone protein	173 Residues from position (27-199)
Receptor	N/A
Gene ID	1444
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 4

HMRbase accession number	10305
Swiss-prot Accession number	P81277 (Sequence in FASTA format)
Description	Prolactin-releasing peptide precursor (PrRP) (Prolactin-releasinghormone) [Contains: Prolactin-releasing peptide PrRP31; Prolactin-releasing peptide PrRP20].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	N/A
Tissue Specificity	Medulla oblongata and hypothalamus
Post translational modification	N/A
Function	Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL
Protein Length	87 Amino acids
Molecular weight	9639
References	1  PubMed abstract 9607765 2  PubMed abstract 15489334 3  PubMed abstract 10498338
Domain Name	N/A
Hormone Name	Prolactin-releasing peptide PrRP31
Mature Hormone Sequence	SRTHRHSMEIRTPDINPAWYASRGIRPVGRF
Position of mature hormone in Pre-Hormone protein	31 Residues from position (23-53)
Receptor	P49683    Detail in HMRbase
Gene ID	51052
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 5

HMRbase accession number	10306
Swiss-prot Accession number	P81277 (Sequence in FASTA format)
Description	Prolactin-releasing peptide precursor (PrRP) (Prolactin-releasinghormone) [Contains: Prolactin-releasing peptide PrRP31; Prolactin-releasing peptide PrRP20].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	N/A
Tissue Specificity	Medulla oblongata and hypothalamus
Post translational modification	N/A
Function	Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL
Protein Length	87 Amino acids
Molecular weight	9639
References	1  PubMed abstract 9607765 2  PubMed abstract 15489334 3  PubMed abstract 10498338
Domain Name	N/A
Hormone Name	Prolactin-releasing peptide PrRP20
Mature Hormone Sequence	TPDINPAWYASRGIRPVGRF
Position of mature hormone in Pre-Hormone protein	20 Residues from position (34-53)
Receptor	P49683    Detail in HMRbase
Gene ID	51052
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 6

HMRbase accession number	10320
Swiss-prot Accession number	Q16048 (Sequence in FASTA format)
Description	Pro-MCH-like protein 1 (Pro-melanin-concentrating hormone-like protein1) (Pro-MCH variant).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	N/A
Developmental Stage	Expressed in developing brain, found in fetal newborn and adult brain.
Similarity	Belongs to the melanin-concentrating hormone family.
Tissue Specificity	Expressed in testis and brain
Post translational modification	N/A
Function	N/A
Protein Length	86 Amino acids
Molecular weight	9715
References	1  PubMed abstract 11181993 2  PubMed abstract 8326825 3  PubMed abstract 9729295 4  PubMed abstract 11070051
Domain Name	Pro-MCH
Hormone Name	Melanin-concentrating hormone-like
Mature Hormone Sequence	DFDTLSCMLGRVYQSCWQV
Position of mature hormone in Pre-Hormone protein	19 Residues from position (68-86)
Receptor	Q99705   Detail in HMRbase    Q969V1    Detail in HMRbase
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 7

HMRbase accession number	10331
Swiss-prot Accession number	Q6X4W1 (Sequence in FASTA format)
Description	Nasal embryonic luteinizing hormone-releasing hormone factor (Nasalembryonic LHRH factor).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Cell membrane; peripheral membrane protein (By similarity). Note=Found on the outside of the LHRH cell membrane and axons projecting from the olfactory pit and epithelium (By similarity)
Developmental Stage	N/A
Similarity	N/A
Tissue Specificity	Highly expressed in adult and fetal brain, testis and kidney
Post translational modification	N/A
Function	Influences outgrowth of olfactory axons and migration of LHRH neurons
Protein Length	530 Amino acids
Molecular weight	60143
References	1  PubMed abstract 15362570 2  PubMed abstract 14702039 3  PubMed abstract 15164053 4  PubMed abstract 15489334 5   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases. 6  PubMed abstract 16565220
Domain Name	N/A
Hormone Name	Nasal embryonic luteinizing hormone-releasing hormone factor
Mature Hormone Sequence	MGAAASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGADHLLADAYSGHDGSPEMQPAPQNKRRLSLVSNGCYEGSLSEEPSIRKPAGEGPQPRVYTISGEPALLPSPEAEAIELAVVKGRRQRHPHHHSQPLRASPGGSREDVSRPCQSWAGSRQGSKECPGCAQLAPGPTPRAFGLDQPPLPETSGRRKKLERMYSVDRVSDDIPIRTWFPKENLFSFQTATTTMQAISVFRGYAERKRRKRENDSASVIQRNFRKHLRMVGSRRVKAQTFAERRERSFSRSWSDPTPMKADTSHDSRDSSDLQSSHCTLDEAFEDLDWDTEKGLEAVACDTEGFVPPKVMLISSKVPKAEYIPTIIRRDDPSIIPILYDHEHATFEDILEEIERKLNVYHKGAKIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMIHFWKRLSRLMSKVNPEPNVIHIMGCYILGNPNGEKLFQNLRTLMTPYRVTFESPLELSAQGKQMIETYFDFRLYRLWKSRQHSKLLDFDDVL
Position of mature hormone in Pre-Hormone protein	530 Residues from position (1-530)
Receptor	P30968    Detail in HMRbase
Gene ID	26012
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 8

HMRbase accession number	10338
Swiss-prot Accession number	Q8WXF3 (Sequence in FASTA format)
Description	Relaxin-3 precursor (Prorelaxin H3) (Insulin-like peptide INSL7)(Insulin-like peptide 7) [Contains: Relaxin-3 B chain; Relaxin-3 Achain].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142).
Protein Length	142 Amino acids
Molecular weight	15451
References	1   Holloway J.L., Lok S., Jaspers S.R.; "Homo sapiens insulin homolog polypeptide."; Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases. 2  PubMed abstract 12686464 3  PubMed abstract 12975309 4  PubMed abstract 12506116 5  PubMed abstract 14522968 6  PubMed abstract 14522967
Domain Name	N/A
Hormone Name	Relaxin-3 B chain
Mature Hormone Sequence	RAAPYGVRLCGREFIRAVIFTCGGSRW
Position of mature hormone in Pre-Hormone protein	27 Residues from position (26-52)
Receptor	Q9NSD7   Detail in HMRbase    Q8TDU9   Detail in HMRbase    Q9HBX9   Detail in HMRbase    Q8WXD0    Detail in HMRbase
Gene ID	117579
PDB ID	2FHW
Drugpedia	wiki
Comments

Search Result - 9

HMRbase accession number	10339
Swiss-prot Accession number	Q8WXF3 (Sequence in FASTA format)
Description	Relaxin-3 precursor (Prorelaxin H3) (Insulin-like peptide INSL7)(Insulin-like peptide 7) [Contains: Relaxin-3 B chain; Relaxin-3 Achain].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142).
Protein Length	142 Amino acids
Molecular weight	15451
References	1   Holloway J.L., Lok S., Jaspers S.R.; "Homo sapiens insulin homolog polypeptide."; Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases. 2  PubMed abstract 12686464 3  PubMed abstract 12975309 4  PubMed abstract 12506116 5  PubMed abstract 14522968 6  PubMed abstract 14522967
Domain Name	N/A
Hormone Name	Relaxin-3 A chain
Mature Hormone Sequence	DVLAGLSSSCCKWGCSKSEISSLC
Position of mature hormone in Pre-Hormone protein	24 Residues from position (119-142)
Receptor	Q9NSD7   Detail in HMRbase    Q8TDU9   Detail in HMRbase    Q9HBX9   Detail in HMRbase    Q8WXD0    Detail in HMRbase
Gene ID	117579
PDB ID	2FHW
Drugpedia	wiki
Comments

Search Result - 10

HMRbase accession number	10345
Swiss-prot Accession number	Q96T91 (Sequence in FASTA format)
Description	Glycoprotein hormone alpha-2 precursor (Thyrostimulin subunit alpha).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the glycoprotein hormones subunit alpha family.
Tissue Specificity	Found in a variety of tissues
Post translational modification	Glycosylated.
Function	Stimulates the thyroid. Binds and activates THSR, leads to increased cAMP production
Protein Length	129 Amino acids
Molecular weight	14163
References	1   Ching A., Gilbert T., Lok S., Sheppard P., Webster P., O'Hara P.J.; "A novel cysteine knot protein expressed in pancreatic acinar cells."; Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases. 2  PubMed abstract 15489334 3  PubMed abstract 12045258 4  PubMed abstract 12089349
Domain Name	N/A
Hormone Name	Glycoprotein hormone alpha-2
Mature Hormone Sequence	QEAVIPGCHLHPFNVTVRSDRQGTCQGSHVAQACVGHCESSAFPSRYSVLVASGYRHNITSVSQCCTISGLKKVKVQLQCVGSRREELEIFTARACQCDMCRLSRY
Position of mature hormone in Pre-Hormone protein	106 Residues from position (24-129)
Receptor	P16473    Detail in HMRbase
Gene ID	170589
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 11

HMRbase accession number	10367
Swiss-prot Accession number	Q9UBU3 (Sequence in FASTA format)
Description	Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide) (M46protein) [Contains: Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the motilin family.
Tissue Specificity	Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy
Post translational modification	O-n-octanoylation is essential for ghrelin activity. The O-n- decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser- 26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with an unsaturated carboxylic acid. Amidation of Leu-98 is essential for obestatin activity (By similarity).
Function	Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation
Protein Length	117 Amino acids
Molecular weight	12911
References	1  PubMed abstract 10604470 2  PubMed abstract 10930375 3   Wajnrajch M.P., Ten I.S., Gertner J.M., Leibel R.L.; "Genomic organization of the human Ghrelin gene."; J. Endocr. Genet. 1:231-233(2000). 4  PubMed abstract 12414809 5  PubMed abstract 12975309 6  PubMed abstract 15489334 7  PubMed abstract 15340161 8  PubMed abstract 11306336
Domain Name	Motilin_assoc  Motilin_ghrelin
Hormone Name	Ghrelin-28
Mature Hormone Sequence	GSSFLSPEHQRVQQRKESKKPPAKLQPR
Position of mature hormone in Pre-Hormone protein	28 Residues from position (24-51)
Receptor	Q02643    Detail in HMRbase
Gene ID	51738
PDB ID	1P7X
Drugpedia	wiki
Comments

Search Result - 12

HMRbase accession number	10368
Swiss-prot Accession number	Q9UBU3 (Sequence in FASTA format)
Description	Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide) (M46protein) [Contains: Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the motilin family.
Tissue Specificity	Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy
Post translational modification	O-n-octanoylation is essential for ghrelin activity. The O-n- decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser- 26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with an unsaturated carboxylic acid. Amidation of Leu-98 is essential for obestatin activity (By similarity).
Function	Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation
Protein Length	117 Amino acids
Molecular weight	12911
References	1  PubMed abstract 10604470 2  PubMed abstract 10930375 3   Wajnrajch M.P., Ten I.S., Gertner J.M., Leibel R.L.; "Genomic organization of the human Ghrelin gene."; J. Endocr. Genet. 1:231-233(2000). 4  PubMed abstract 12414809 5  PubMed abstract 12975309 6  PubMed abstract 15489334 7  PubMed abstract 15340161 8  PubMed abstract 11306336
Domain Name	Motilin_assoc  Motilin_ghrelin
Hormone Name	Ghrelin-27
Mature Hormone Sequence	GSSFLSPEHQRVQQRKESKKPPAKLQP
Position of mature hormone in Pre-Hormone protein	27 Residues from position (24-50)
Receptor	Q02643    Detail in HMRbase
Gene ID	51738
PDB ID	1P7X
Drugpedia	wiki
Comments

Search Result - 13

HMRbase accession number	10369
Swiss-prot Accession number	Q9UBU3 (Sequence in FASTA format)
Description	Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide) (M46protein) [Contains: Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the motilin family.
Tissue Specificity	Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy
Post translational modification	O-n-octanoylation is essential for ghrelin activity. The O-n- decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser- 26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with an unsaturated carboxylic acid. Amidation of Leu-98 is essential for obestatin activity (By similarity).
Function	Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility
Protein Length	117 Amino acids
Molecular weight	12911
References	1  PubMed abstract 10604470 2  PubMed abstract 10930375 3   Wajnrajch M.P., Ten I.S., Gertner J.M., Leibel R.L.; "Genomic organization of the human Ghrelin gene."; J. Endocr. Genet. 1:231-233(2000). 4  PubMed abstract 12414809 5  PubMed abstract 12975309 6  PubMed abstract 15489334 7  PubMed abstract 15340161 8  PubMed abstract 11306336
Domain Name	Motilin_assoc  Motilin_ghrelin
Hormone Name	Obestatin
Mature Hormone Sequence	FNAPFDVGIKLSGVQYQQHSQAL
Position of mature hormone in Pre-Hormone protein	23 Residues from position (76-98)
Receptor	Q02643    Detail in HMRbase
Gene ID	51738
PDB ID	1P7X
Drugpedia	wiki
Comments

Search Result - 14

HMRbase accession number	10595
Swiss-prot Accession number	P01243 (Sequence in FASTA format)
Description	Chorionic somatomammotropin hormone precursor (Choriomammotropin)(Lactogen).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the somatotropin/prolactin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Similar to that of somatotropin
Protein Length	217 Amino acids
Molecular weight	25020
References	1  PubMed abstract 6208192 2  PubMed abstract 3030680 3  PubMed abstract 6300056 4  PubMed abstract 2744760 5  PubMed abstract 7169009 6   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 7  PubMed abstract 15489334 8  PubMed abstract 593368 9  PubMed abstract 4712450 10  PubMed abstract 5286363 11   Sherwood L.M., Handwerger S., McLaurin W.D., Lanner M.; Nature New Biol. 235:64-64(1972). 12  PubMed abstract 438159
Domain Name	Hormone_1
Hormone Name	Chorionic somatomammotropin hormone (Choriomammotropin) (Lactogen)
Mature Hormone Sequence	VQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEETYIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLRSMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTNSHNHDALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF
Position of mature hormone in Pre-Hormone protein	191 Residues from position (27-217)
Receptor	N/A
Gene ID	1442
PDB ID	1Z7C
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 15

HMRbase accession number	10681
Swiss-prot Accession number	P01298 (Sequence in FASTA format)
Description	Pancreatic prohormone precursor (Pancreatic polypeptide) (PP)[Contains: Pancreatic hormone; Pancreatic icosapeptide].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the NPY family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions
Protein Length	95 Amino acids
Molecular weight	10445
References	1  PubMed abstract 6373251 2  PubMed abstract 2997153 3  PubMed abstract 6094571 4  PubMed abstract 3753985 5  PubMed abstract 15489334 6  PubMed abstract 6366786 7  PubMed abstract 15966750
Domain Name	Hormone_3
Hormone Name	Pancreatic hormone
Mature Hormone Sequence	APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY
Position of mature hormone in Pre-Hormone protein	36 Residues from position (30-65)
Receptor	N/A
Gene ID	5539
PDB ID	1TZ4   1TZ5
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 16

HMRbase accession number	10682
Swiss-prot Accession number	P01298 (Sequence in FASTA format)
Description	Pancreatic prohormone precursor (Pancreatic polypeptide) (PP)[Contains: Pancreatic hormone; Pancreatic icosapeptide].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the NPY family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	The physiological role for the icosapeptide has not yet been elucidated
Protein Length	95 Amino acids
Molecular weight	10445
References	1  PubMed abstract 6373251 2  PubMed abstract 2997153 3  PubMed abstract 6094571 4  PubMed abstract 3753985 5  PubMed abstract 15489334 6  PubMed abstract 6366786 7  PubMed abstract 15966750
Domain Name	Hormone_3
Hormone Name	Pancreatic icosapeptide
Mature Hormone Sequence	HKEDTLAFSEWGSPHAAVPR
Position of mature hormone in Pre-Hormone protein	20 Residues from position (69-88)
Receptor	N/A
Gene ID	5539
PDB ID	1TZ4   1TZ5
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 17

HMRbase accession number	10708
Swiss-prot Accession number	P01242 (Sequence in FASTA format)
Description	Growth hormone variant precursor (GH-V) (Placenta-specific growthhormone) (Growth hormone 2).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the somatotropin/prolactin family.
Tissue Specificity	Expressed in the placenta
Post translational modification	N/A
Function	Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues
Protein Length	217 Amino acids
Molecular weight	25000
References	1  PubMed abstract 7169009 2  PubMed abstract 3379057 3  PubMed abstract 2460050 4  PubMed abstract 2744760 5  PubMed abstract 15489334 6  PubMed abstract 2196278 7  PubMed abstract 10393484
Domain Name	Hormone_1
Hormone Name	Growth hormone 2 (Placenta-specific growth hormone) (GH-V)
Mature Hormone Sequence	FPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEAYILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLRSVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF
Position of mature hormone in Pre-Hormone protein	191 Residues from position (27-217)
Receptor	N/A
Gene ID	2689
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 18

HMRbase accession number	11039
Swiss-prot Accession number	P06454 (Sequence in FASTA format)
Description	Prothymosin alpha [Contains: Thymosin alpha-1].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Nucleus
Developmental Stage	N/A
Similarity	Belongs to the pro/parathymosin family.
Tissue Specificity	N/A
Post translational modification	Covalently linked to a small RNA of about 20 nucleotides (By similarity).
Function	Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections
Protein Length	111 Amino acids
Molecular weight	12203
References	1  PubMed abstract 3467312 2  PubMed abstract 3466166 3  PubMed abstract 2708378 4  PubMed abstract 2785990 5   Li Z., Fan Q., Huang W., An L.; "A novel prothymosin alpha cDNA from thymus."; Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases. 6  PubMed abstract 15489334 7  PubMed abstract 7916742 8  PubMed abstract 3532956 9  PubMed abstract 8485135 10  PubMed abstract 17081983
Domain Name	Prothymosin
Hormone Name	Prothymosin alpha
Mature Hormone Sequence	SDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNAENEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAESATGKRAAEDDEDDDVDTKKQKTDEDD
Position of mature hormone in Pre-Hormone protein	110 Residues from position (2-111)
Receptor	N/A
Gene ID	5757
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 19

HMRbase accession number	11040
Swiss-prot Accession number	P06454 (Sequence in FASTA format)
Description	Prothymosin alpha [Contains: Thymosin alpha-1].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Nucleus
Developmental Stage	N/A
Similarity	Belongs to the pro/parathymosin family.
Tissue Specificity	N/A
Post translational modification	Covalently linked to a small RNA of about 20 nucleotides (By similarity).
Function	Thymosin alpha1 (Talpha1) is an oligopeptide hormone originally isolated from the thymus gland, and has been reported to have stimulating effects on the differentiation of T cells and NK cells
Protein Length	111 Amino acids
Molecular weight	12203
References	1  PubMed abstract 3467312 2  PubMed abstract 3466166 3  PubMed abstract 2708378 4  PubMed abstract 2785990 5   Li Z., Fan Q., Huang W., An L.; "A novel prothymosin alpha cDNA from thymus."; Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases. 6  PubMed abstract 15489334 7  PubMed abstract 7916742 8  PubMed abstract 3532956 9  PubMed abstract 8485135 10  PubMed abstract 17081983
Domain Name	Prothymosin
Hormone Name	Thymosin alpha-1
Mature Hormone Sequence	SDAAVDTSSEITTKDLKEKKEVVEEAEN
Position of mature hormone in Pre-Hormone protein	28 Residues from position (2-29)
Receptor	N/A
Gene ID	5757
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 20

HMRbase accession number	11048
Swiss-prot Accession number	P63313 (Sequence in FASTA format)
Description	Thymosin beta-10.
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Cytoplasm
Developmental Stage	Found to decrease dramatically after birth.
Similarity	Belongs to the thymosin beta family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization
Protein Length	44 Amino acids
Molecular weight	5026
References	1  PubMed abstract 3365256 2  PubMed abstract 2169566 3  PubMed abstract 8425765 4   Condon M.R., Hall A.K.; "Human thymosin beta 10 gene: its characterization and nucleotidesequence."; Submitted (APR-1992) to the EMBL/GenBank/DDBJ databases. 5  PubMed abstract 15489334 6  PubMed abstract 16916647
Domain Name	Thymosin
Hormone Name	Thymosin beta-10
Mature Hormone Sequence	ADKPDMGEIASFDKAKLKKTETQEKNTLPTKETIEQEKRSEIS
Position of mature hormone in Pre-Hormone protein	43 Residues from position (2-44)
Receptor	N/A
Gene ID	9168
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 21

HMRbase accession number	11054
Swiss-prot Accession number	O14604 (Sequence in FASTA format)
Description	Thymosin beta-4, Y-chromosomal.
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Cytoplasm (By similarity)
Developmental Stage	N/A
Similarity	Belongs to the thymosin beta family.
Tissue Specificity	Ubiquitous
Post translational modification	N/A
Function	Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization
Protein Length	44 Amino acids
Molecular weight	5013
References	1  PubMed abstract 9381176 2  PubMed abstract 12815422 3  PubMed abstract 15489334
Domain Name	Thymosin
Hormone Name	Thymosin beta-4
Mature Hormone Sequence	SDKPGMAEIEKFDKSKLKKTETQEKNPLSSKETIEQERQAGES
Position of mature hormone in Pre-Hormone protein	43 Residues from position (2-44)
Receptor	N/A
Gene ID	100130227   9087
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 22

HMRbase accession number	11059
Swiss-prot Accession number	P62328 (Sequence in FASTA format)
Description	Thymosin beta-4 (T beta 4) (Fx) [Contains: Hematopoietic systemregulatory peptide (Seraspenide)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Cytoplasm
Developmental Stage	N/A
Similarity	Belongs to the thymosin beta family.
Tissue Specificity	Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells
Post translational modification	N/A
Function	Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization
Protein Length	44 Amino acids
Molecular weight	5053
References	1  PubMed abstract 3500230 2  PubMed abstract 16010977 3   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 4  PubMed abstract 1999398 5  PubMed abstract 6548414 6  PubMed abstract 10848969
Domain Name	Thymosin
Hormone Name	Thymosin beta-4
Mature Hormone Sequence	SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES
Position of mature hormone in Pre-Hormone protein	43 Residues from position (2-44)
Receptor	N/A
Gene ID	7114
PDB ID	1UY5
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 23

HMRbase accession number	11060
Swiss-prot Accession number	P62328 (Sequence in FASTA format)
Description	Thymosin beta-4 (T beta 4) (Fx) [Contains: Hematopoietic systemregulatory peptide (Seraspenide)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Cytoplasm
Developmental Stage	N/A
Similarity	Belongs to the thymosin beta family.
Tissue Specificity	Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells
Post translational modification	N/A
Function	Seraspenide inhibits the entry of hematopoeitic pluripotent stem cells into the S-phase
Protein Length	44 Amino acids
Molecular weight	5053
References	1  PubMed abstract 3500230 2  PubMed abstract 16010977 3   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 4  PubMed abstract 1999398 5  PubMed abstract 6548414 6  PubMed abstract 10848969
Domain Name	Thymosin
Hormone Name	Hematopoietic system regulatory peptide
Mature Hormone Sequence	SDKP
Position of mature hormone in Pre-Hormone protein	4 Residues from position (2-5)
Receptor	N/A
Gene ID	7114
PDB ID	1UY5
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 24

HMRbase accession number	11173
Swiss-prot Accession number	P06307 (Sequence in FASTA format)
Description	Cholecystokinins precursor (CCK) [Contains: Cholecystokinin 58(CCK58); Cholecystokinin 39 (CCK39); Cholecystokinin 33 (CCK33);Cholecystokinin 12 (CCK12); Cholecystokinin 8 (CCK8)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the gastrin/cholecystokinin family.
Tissue Specificity	N/A
Post translational modification	The precursor cleaved by enzymes to produce a number of active cholecystokinins.
Function	This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion
Protein Length	115 Amino acids
Molecular weight	12669
References	1  PubMed abstract 3856870 2   Kato K., Takahashi Y., Matsubara K.; "Molecular cloning of the human cholecystokinin gene."; Ann. N. Y. Acad. Sci. 448:613-615(1985). 3   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 4   Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N.,Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S.,Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Departmentof Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. 5  PubMed abstract 15489334 6  PubMed abstract 11076522
Domain Name	Gastrin
Hormone Name	Cholecystokinin-12
Mature Hormone Sequence	ISDRDYMGWMDF
Position of mature hormone in Pre-Hormone protein	12 Residues from position (92-103)
Receptor	P32239   Detail in HMRbase    P32238    Detail in HMRbase
Gene ID	885
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 25

HMRbase accession number	11197
Swiss-prot Accession number	P09681 (Sequence in FASTA format)
Description	Gastric inhibitory polypeptide precursor (GIP) (Glucose-dependentinsulinotropic polypeptide).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the glucagon family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion
Protein Length	153 Amino acids
Molecular weight	17108
References	1  PubMed abstract 2890159 2  PubMed abstract 2739653 3  PubMed abstract 15489334 4  PubMed abstract 6745415 5  PubMed abstract 15522230
Domain Name	Hormone_2
Hormone Name	Gastric inhibitory polypeptide
Mature Hormone Sequence	YAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ
Position of mature hormone in Pre-Hormone protein	42 Residues from position (52-93)
Receptor	N/A
Gene ID	2695
PDB ID	1T5Q   2B4N
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 26

HMRbase accession number	11235
Swiss-prot Accession number	O43555 (Sequence in FASTA format)
Description	Progonadoliberin-2 precursor (Progonadoliberin II) [Contains:Gonadoliberin-2 (Gonadoliberin II) (Luteinizing hormone-releasinghormone II) (LH-RH II) (Gonadotropin-releasing hormone II) (GnRH II)(Luliberin II); GnRH-associated peptide 2 (GnRH-associated peptideII)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the GnRH family.
Tissue Specificity	Midbrain; expressed at significantly higher levels outside the brain (up to 30-fold), particularly in the kidney, bone marrow and prostate
Post translational modification	N/A
Function	Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones
Protein Length	120 Amino acids
Molecular weight	12918
References	1  PubMed abstract 9419371 2  PubMed abstract 11780052 3  PubMed abstract 15489334
Domain Name	N/A
Hormone Name	Gonadoliberin-2
Mature Hormone Sequence	QHWSHGWYPG
Position of mature hormone in Pre-Hormone protein	10 Residues from position (24-33)
Receptor	P30968   Detail in HMRbase    Q96P88    Detail in HMRbase
Gene ID	2797
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 27

HMRbase accession number	11243
Swiss-prot Accession number	P01148 (Sequence in FASTA format)
Description	Progonadoliberin-1 precursor (Progonadoliberin I) [Contains:Gonadoliberin-1 (Gonadoliberin I) (Luteinizing hormone-releasinghormone I) (LH-RH I) (Gonadotropin-releasing hormone I) (GnRH-I)(Luliberin I) (Gonadorelin); GnRH-associated peptide 1 (GnRH-associated peptide I)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the GnRH family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones
Protein Length	92 Amino acids
Molecular weight	10380
References	1  PubMed abstract 2671939 2  PubMed abstract 2867548 3  PubMed abstract 6090951 4  PubMed abstract 15489334 5  PubMed abstract 6760865 6  PubMed abstract 10391209 7   Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999).
Domain Name	N/A
Hormone Name	Gonadoliberin-1
Mature Hormone Sequence	QHWSYGLRPG
Position of mature hormone in Pre-Hormone protein	10 Residues from position (24-33)
Receptor	P30968    Detail in HMRbase
Gene ID	2796
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 28

HMRbase accession number	11250
Swiss-prot Accession number	P01189 (Sequence in FASTA format)
Description	Corticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide;Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha(Alpha-MSH); Corticotropin-like intermediary peptide (CLIP);Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropinbeta (Beta-MSH); Beta-endorphin; Met-enkephalin].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	N/A
Developmental Stage	N/A
Similarity	Belongs to the POMC family.
Tissue Specificity	ACTH and MSH are produced by the pituitary gland
Post translational modification	Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N- acetylgalactosamine.
Function	MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes
Protein Length	267 Amino acids
Molecular weight	29424
References	1  PubMed abstract 6274691 2  PubMed abstract 6299668 3  PubMed abstract 6314261 4  PubMed abstract 15489334 5  PubMed abstract 3606677 6  PubMed abstract 6254047 7  PubMed abstract 6945581 8  PubMed abstract 6267033 9  PubMed abstract 6272808 10  PubMed abstract 4352834 11  PubMed abstract 14463577 12  PubMed abstract 15340161 13  PubMed abstract 4334191 14  PubMed abstract 4338630 15  PubMed abstract 4347148 16  PubMed abstract 1264228 17   Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 18  PubMed abstract 195688 19  PubMed abstract 2424570 20  PubMed abstract 2839146 21  PubMed abstract 7828531 22  PubMed abstract 9620771 23  PubMed abstract 16046320 24  PubMed abstract 16807684 25  PubMed abstract 9768693 26  PubMed abstract 10193875 27  PubMed abstract 11244459 28  PubMed abstract 12165561 29  PubMed abstract 6274691 30  PubMed abstract 6299668 31  PubMed abstract 6314261 32  PubMed abstract 15489334 33  PubMed abstract 3606677 34  PubMed abstract 6254047 35  PubMed abstract 6945581 36  PubMed abstract 6267033 37  PubMed abstract 6272808 38  PubMed abstract 4352834 39  PubMed abstract 14463577 40  PubMed abstract 15340161 41  PubMed abstract 4334191 42  PubMed abstract 4338630 43  PubMed abstract 4347148 44  PubMed abstract 1264228 45   Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 46  PubMed abstract 195688 47  PubMed abstract 2424570 48  PubMed abstract 2839146 49  PubMed abstract 7828531 50  PubMed abstract 9620771 51  PubMed abstract 16046320 52  PubMed abstract 16807684 53  PubMed abstract 9768693 54  PubMed abstract 10193875 55  PubMed abstract 11244459 56  PubMed abstract 12165561
Domain Name	ACTH_domain  NPP  Op_neuropeptide
Hormone Name	Melanotropin gamma (Gamma-MSH)
Mature Hormone Sequence	YVMGHFRWDRF
Position of mature hormone in Pre-Hormone protein	11 Residues from position (77-87)
Receptor	Q01726    Detail in HMRbase
Gene ID	5443
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 29

HMRbase accession number	11251
Swiss-prot Accession number	P01189 (Sequence in FASTA format)
Description	Corticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide;Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha(Alpha-MSH); Corticotropin-like intermediary peptide (CLIP);Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropinbeta (Beta-MSH); Beta-endorphin; Met-enkephalin].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	N/A
Developmental Stage	N/A
Similarity	Belongs to the POMC family.
Tissue Specificity	ACTH and MSH are produced by the pituitary gland
Post translational modification	Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N- acetylgalactosamine.
Function	ACTH stimulates the adrenal glands to release cortisol
Protein Length	267 Amino acids
Molecular weight	29424
References	1  PubMed abstract 6274691 2  PubMed abstract 6299668 3  PubMed abstract 6314261 4  PubMed abstract 15489334 5  PubMed abstract 3606677 6  PubMed abstract 6254047 7  PubMed abstract 6945581 8  PubMed abstract 6267033 9  PubMed abstract 6272808 10  PubMed abstract 4352834 11  PubMed abstract 14463577 12  PubMed abstract 15340161 13  PubMed abstract 4334191 14  PubMed abstract 4338630 15  PubMed abstract 4347148 16  PubMed abstract 1264228 17   Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 18  PubMed abstract 195688 19  PubMed abstract 2424570 20  PubMed abstract 2839146 21  PubMed abstract 7828531 22  PubMed abstract 9620771 23  PubMed abstract 16046320 24  PubMed abstract 16807684 25  PubMed abstract 9768693 26  PubMed abstract 10193875 27  PubMed abstract 11244459 28  PubMed abstract 12165561 29  PubMed abstract 6274691 30  PubMed abstract 6299668 31  PubMed abstract 6314261 32  PubMed abstract 15489334 33  PubMed abstract 3606677 34  PubMed abstract 6254047 35  PubMed abstract 6945581 36  PubMed abstract 6267033 37  PubMed abstract 6272808 38  PubMed abstract 4352834 39  PubMed abstract 14463577 40  PubMed abstract 15340161 41  PubMed abstract 4334191 42  PubMed abstract 4338630 43  PubMed abstract 4347148 44  PubMed abstract 1264228 45   Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 46  PubMed abstract 195688 47  PubMed abstract 2424570 48  PubMed abstract 2839146 49  PubMed abstract 7828531 50  PubMed abstract 9620771 51  PubMed abstract 16046320 52  PubMed abstract 16807684 53  PubMed abstract 9768693 54  PubMed abstract 10193875 55  PubMed abstract 11244459 56  PubMed abstract 12165561
Domain Name	ACTH_domain  NPP  Op_neuropeptide
Hormone Name	Corticotropin
Mature Hormone Sequence	SYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEF
Position of mature hormone in Pre-Hormone protein	39 Residues from position (138-176)
Receptor	Q01726    Detail in HMRbase
Gene ID	5443
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 30

HMRbase accession number	11252
Swiss-prot Accession number	P01189 (Sequence in FASTA format)
Description	Corticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide;Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha(Alpha-MSH); Corticotropin-like intermediary peptide (CLIP);Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropinbeta (Beta-MSH); Beta-endorphin; Met-enkephalin].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	N/A
Developmental Stage	N/A
Similarity	Belongs to the POMC family.
Tissue Specificity	ACTH and MSH are produced by the pituitary gland
Post translational modification	Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N- acetylgalactosamine.
Function	MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes
Protein Length	267 Amino acids
Molecular weight	29424
References	1  PubMed abstract 6274691 2  PubMed abstract 6299668 3  PubMed abstract 6314261 4  PubMed abstract 15489334 5  PubMed abstract 3606677 6  PubMed abstract 6254047 7  PubMed abstract 6945581 8  PubMed abstract 6267033 9  PubMed abstract 6272808 10  PubMed abstract 4352834 11  PubMed abstract 14463577 12  PubMed abstract 15340161 13  PubMed abstract 4334191 14  PubMed abstract 4338630 15  PubMed abstract 4347148 16  PubMed abstract 1264228 17   Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 18  PubMed abstract 195688 19  PubMed abstract 2424570 20  PubMed abstract 2839146 21  PubMed abstract 7828531 22  PubMed abstract 9620771 23  PubMed abstract 16046320 24  PubMed abstract 16807684 25  PubMed abstract 9768693 26  PubMed abstract 10193875 27  PubMed abstract 11244459 28  PubMed abstract 12165561 29  PubMed abstract 6274691 30  PubMed abstract 6299668 31  PubMed abstract 6314261 32  PubMed abstract 15489334 33  PubMed abstract 3606677 34  PubMed abstract 6254047 35  PubMed abstract 6945581 36  PubMed abstract 6267033 37  PubMed abstract 6272808 38  PubMed abstract 4352834 39  PubMed abstract 14463577 40  PubMed abstract 15340161 41  PubMed abstract 4334191 42  PubMed abstract 4338630 43  PubMed abstract 4347148 44  PubMed abstract 1264228 45   Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 46  PubMed abstract 195688 47  PubMed abstract 2424570 48  PubMed abstract 2839146 49  PubMed abstract 7828531 50  PubMed abstract 9620771 51  PubMed abstract 16046320 52  PubMed abstract 16807684 53  PubMed abstract 9768693 54  PubMed abstract 10193875 55  PubMed abstract 11244459 56  PubMed abstract 12165561
Domain Name	ACTH_domain  NPP  Op_neuropeptide
Hormone Name	Melanotropin alpha (Alpha-MSH)
Mature Hormone Sequence	SYSMEHFRWGKPV
Position of mature hormone in Pre-Hormone protein	13 Residues from position (138-150)
Receptor	Q01726    Detail in HMRbase
Gene ID	5443
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 31

HMRbase accession number	11253
Swiss-prot Accession number	P01189 (Sequence in FASTA format)
Description	Corticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide;Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha(Alpha-MSH); Corticotropin-like intermediary peptide (CLIP);Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropinbeta (Beta-MSH); Beta-endorphin; Met-enkephalin].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	N/A
Developmental Stage	N/A
Similarity	Belongs to the POMC family.
Tissue Specificity	ACTH and MSH are produced by the pituitary gland
Post translational modification	Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N- acetylgalactosamine.
Function	Stimulates melanocytes to produce melanin. It performs lipid-mobilizing functions such as lipolysis and steroidogenesis.
Protein Length	267 Amino acids
Molecular weight	29424
References	1  PubMed abstract 6274691 2  PubMed abstract 6299668 3  PubMed abstract 6314261 4  PubMed abstract 15489334 5  PubMed abstract 3606677 6  PubMed abstract 6254047 7  PubMed abstract 6945581 8  PubMed abstract 6267033 9  PubMed abstract 6272808 10  PubMed abstract 4352834 11  PubMed abstract 14463577 12  PubMed abstract 15340161 13  PubMed abstract 4334191 14  PubMed abstract 4338630 15  PubMed abstract 4347148 16  PubMed abstract 1264228 17   Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 18  PubMed abstract 195688 19  PubMed abstract 2424570 20  PubMed abstract 2839146 21  PubMed abstract 7828531 22  PubMed abstract 9620771 23  PubMed abstract 16046320 24  PubMed abstract 16807684 25  PubMed abstract 9768693 26  PubMed abstract 10193875 27  PubMed abstract 11244459 28  PubMed abstract 12165561 29  PubMed abstract 6274691 30  PubMed abstract 6299668 31  PubMed abstract 6314261 32  PubMed abstract 15489334 33  PubMed abstract 3606677 34  PubMed abstract 6254047 35  PubMed abstract 6945581 36  PubMed abstract 6267033 37  PubMed abstract 6272808 38  PubMed abstract 4352834 39  PubMed abstract 14463577 40  PubMed abstract 15340161 41  PubMed abstract 4334191 42  PubMed abstract 4338630 43  PubMed abstract 4347148 44  PubMed abstract 1264228 45   Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 46  PubMed abstract 195688 47  PubMed abstract 2424570 48  PubMed abstract 2839146 49  PubMed abstract 7828531 50  PubMed abstract 9620771 51  PubMed abstract 16046320 52  PubMed abstract 16807684 53  PubMed abstract 9768693 54  PubMed abstract 10193875 55  PubMed abstract 11244459 56  PubMed abstract 12165561
Domain Name	ACTH_domain  NPP  Op_neuropeptide
Hormone Name	Lipotropin beta (Beta-LPH)
Mature Hormone Sequence	ELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE
Position of mature hormone in Pre-Hormone protein	89 Residues from position (179-267)
Receptor	Q01726    Detail in HMRbase
Gene ID	5443
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 32

HMRbase accession number	11254
Swiss-prot Accession number	P01189 (Sequence in FASTA format)
Description	Corticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide;Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha(Alpha-MSH); Corticotropin-like intermediary peptide (CLIP);Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropinbeta (Beta-MSH); Beta-endorphin; Met-enkephalin].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	N/A
Developmental Stage	N/A
Similarity	Belongs to the POMC family.
Tissue Specificity	ACTH and MSH are produced by the pituitary gland
Post translational modification	Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N- acetylgalactosamine.
Function	Stimulates melanocytes to produce melanin. It performs lipid-mobilizing functions such as lipolysis and steroidogenesis.
Protein Length	267 Amino acids
Molecular weight	29424
References	1  PubMed abstract 6274691 2  PubMed abstract 6299668 3  PubMed abstract 6314261 4  PubMed abstract 15489334 5  PubMed abstract 3606677 6  PubMed abstract 6254047 7  PubMed abstract 6945581 8  PubMed abstract 6267033 9  PubMed abstract 6272808 10  PubMed abstract 4352834 11  PubMed abstract 14463577 12  PubMed abstract 15340161 13  PubMed abstract 4334191 14  PubMed abstract 4338630 15  PubMed abstract 4347148 16  PubMed abstract 1264228 17   Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 18  PubMed abstract 195688 19  PubMed abstract 2424570 20  PubMed abstract 2839146 21  PubMed abstract 7828531 22  PubMed abstract 9620771 23  PubMed abstract 16046320 24  PubMed abstract 16807684 25  PubMed abstract 9768693 26  PubMed abstract 10193875 27  PubMed abstract 11244459 28  PubMed abstract 12165561 29  PubMed abstract 6274691 30  PubMed abstract 6299668 31  PubMed abstract 6314261 32  PubMed abstract 15489334 33  PubMed abstract 3606677 34  PubMed abstract 6254047 35  PubMed abstract 6945581 36  PubMed abstract 6267033 37  PubMed abstract 6272808 38  PubMed abstract 4352834 39  PubMed abstract 14463577 40  PubMed abstract 15340161 41  PubMed abstract 4334191 42  PubMed abstract 4338630 43  PubMed abstract 4347148 44  PubMed abstract 1264228 45   Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 46  PubMed abstract 195688 47  PubMed abstract 2424570 48  PubMed abstract 2839146 49  PubMed abstract 7828531 50  PubMed abstract 9620771 51  PubMed abstract 16046320 52  PubMed abstract 16807684 53  PubMed abstract 9768693 54  PubMed abstract 10193875 55  PubMed abstract 11244459 56  PubMed abstract 12165561
Domain Name	ACTH_domain  NPP  Op_neuropeptide
Hormone Name	Lipotropin gamma (Gamma-LPH)
Mature Hormone Sequence	ELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKD
Position of mature hormone in Pre-Hormone protein	56 Residues from position (179-234)
Receptor	Q01726    Detail in HMRbase
Gene ID	5443
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 33

HMRbase accession number	11255
Swiss-prot Accession number	P01189 (Sequence in FASTA format)
Description	Corticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide;Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha(Alpha-MSH); Corticotropin-like intermediary peptide (CLIP);Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropinbeta (Beta-MSH); Beta-endorphin; Met-enkephalin].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	N/A
Developmental Stage	N/A
Similarity	Belongs to the POMC family.
Tissue Specificity	ACTH and MSH are produced by the pituitary gland
Post translational modification	Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N- acetylgalactosamine.
Function	MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes
Protein Length	267 Amino acids
Molecular weight	29424
References	1  PubMed abstract 6274691 2  PubMed abstract 6299668 3  PubMed abstract 6314261 4  PubMed abstract 15489334 5  PubMed abstract 3606677 6  PubMed abstract 6254047 7  PubMed abstract 6945581 8  PubMed abstract 6267033 9  PubMed abstract 6272808 10  PubMed abstract 4352834 11  PubMed abstract 14463577 12  PubMed abstract 15340161 13  PubMed abstract 4334191 14  PubMed abstract 4338630 15  PubMed abstract 4347148 16  PubMed abstract 1264228 17   Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 18  PubMed abstract 195688 19  PubMed abstract 2424570 20  PubMed abstract 2839146 21  PubMed abstract 7828531 22  PubMed abstract 9620771 23  PubMed abstract 16046320 24  PubMed abstract 16807684 25  PubMed abstract 9768693 26  PubMed abstract 10193875 27  PubMed abstract 11244459 28  PubMed abstract 12165561 29  PubMed abstract 6274691 30  PubMed abstract 6299668 31  PubMed abstract 6314261 32  PubMed abstract 15489334 33  PubMed abstract 3606677 34  PubMed abstract 6254047 35  PubMed abstract 6945581 36  PubMed abstract 6267033 37  PubMed abstract 6272808 38  PubMed abstract 4352834 39  PubMed abstract 14463577 40  PubMed abstract 15340161 41  PubMed abstract 4334191 42  PubMed abstract 4338630 43  PubMed abstract 4347148 44  PubMed abstract 1264228 45   Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 46  PubMed abstract 195688 47  PubMed abstract 2424570 48  PubMed abstract 2839146 49  PubMed abstract 7828531 50  PubMed abstract 9620771 51  PubMed abstract 16046320 52  PubMed abstract 16807684 53  PubMed abstract 9768693 54  PubMed abstract 10193875 55  PubMed abstract 11244459 56  PubMed abstract 12165561
Domain Name	ACTH_domain  NPP  Op_neuropeptide
Hormone Name	Melanotropin beta (Beta-MSH)
Mature Hormone Sequence	DEGPYRMEHFRWGSPPKD
Position of mature hormone in Pre-Hormone protein	18 Residues from position (217-234)
Receptor	Q01726    Detail in HMRbase
Gene ID	5443
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 34

HMRbase accession number	11256
Swiss-prot Accession number	P01189 (Sequence in FASTA format)
Description	Corticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide;Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha(Alpha-MSH); Corticotropin-like intermediary peptide (CLIP);Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropinbeta (Beta-MSH); Beta-endorphin; Met-enkephalin].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	N/A
Developmental Stage	N/A
Similarity	Belongs to the POMC family.
Tissue Specificity	ACTH and MSH are produced by the pituitary gland
Post translational modification	Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N- acetylgalactosamine.
Function	Beta-endorphin is an endogenous opiate
Protein Length	267 Amino acids
Molecular weight	29424
References	1  PubMed abstract 6274691 2  PubMed abstract 6299668 3  PubMed abstract 6314261 4  PubMed abstract 15489334 5  PubMed abstract 3606677 6  PubMed abstract 6254047 7  PubMed abstract 6945581 8  PubMed abstract 6267033 9  PubMed abstract 6272808 10  PubMed abstract 4352834 11  PubMed abstract 14463577 12  PubMed abstract 15340161 13  PubMed abstract 4334191 14  PubMed abstract 4338630 15  PubMed abstract 4347148 16  PubMed abstract 1264228 17   Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 18  PubMed abstract 195688 19  PubMed abstract 2424570 20  PubMed abstract 2839146 21  PubMed abstract 7828531 22  PubMed abstract 9620771 23  PubMed abstract 16046320 24  PubMed abstract 16807684 25  PubMed abstract 9768693 26  PubMed abstract 10193875 27  PubMed abstract 11244459 28  PubMed abstract 12165561 29  PubMed abstract 6274691 30  PubMed abstract 6299668 31  PubMed abstract 6314261 32  PubMed abstract 15489334 33  PubMed abstract 3606677 34  PubMed abstract 6254047 35  PubMed abstract 6945581 36  PubMed abstract 6267033 37  PubMed abstract 6272808 38  PubMed abstract 4352834 39  PubMed abstract 14463577 40  PubMed abstract 15340161 41  PubMed abstract 4334191 42  PubMed abstract 4338630 43  PubMed abstract 4347148 44  PubMed abstract 1264228 45   Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 46  PubMed abstract 195688 47  PubMed abstract 2424570 48  PubMed abstract 2839146 49  PubMed abstract 7828531 50  PubMed abstract 9620771 51  PubMed abstract 16046320 52  PubMed abstract 16807684 53  PubMed abstract 9768693 54  PubMed abstract 10193875 55  PubMed abstract 11244459 56  PubMed abstract 12165561
Domain Name	ACTH_domain  NPP  Op_neuropeptide
Hormone Name	Beta-endorphin
Mature Hormone Sequence	YGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE
Position of mature hormone in Pre-Hormone protein	31 Residues from position (237-267)
Receptor	Q01726    Detail in HMRbase
Gene ID	5443
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 35

HMRbase accession number	11257
Swiss-prot Accession number	P01189 (Sequence in FASTA format)
Description	Corticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide;Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha(Alpha-MSH); Corticotropin-like intermediary peptide (CLIP);Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropinbeta (Beta-MSH); Beta-endorphin; Met-enkephalin].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	N/A
Developmental Stage	N/A
Similarity	Belongs to the POMC family.
Tissue Specificity	ACTH and MSH are produced by the pituitary gland
Post translational modification	Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N- acetylgalactosamine.
Function	Met-enkephalin is an endogenous opiate
Protein Length	267 Amino acids
Molecular weight	29424
References	1  PubMed abstract 6274691 2  PubMed abstract 6299668 3  PubMed abstract 6314261 4  PubMed abstract 15489334 5  PubMed abstract 3606677 6  PubMed abstract 6254047 7  PubMed abstract 6945581 8  PubMed abstract 6267033 9  PubMed abstract 6272808 10  PubMed abstract 4352834 11  PubMed abstract 14463577 12  PubMed abstract 15340161 13  PubMed abstract 4334191 14  PubMed abstract 4338630 15  PubMed abstract 4347148 16  PubMed abstract 1264228 17   Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 18  PubMed abstract 195688 19  PubMed abstract 2424570 20  PubMed abstract 2839146 21  PubMed abstract 7828531 22  PubMed abstract 9620771 23  PubMed abstract 16046320 24  PubMed abstract 16807684 25  PubMed abstract 9768693 26  PubMed abstract 10193875 27  PubMed abstract 11244459 28  PubMed abstract 12165561 29  PubMed abstract 6274691 30  PubMed abstract 6299668 31  PubMed abstract 6314261 32  PubMed abstract 15489334 33  PubMed abstract 3606677 34  PubMed abstract 6254047 35  PubMed abstract 6945581 36  PubMed abstract 6267033 37  PubMed abstract 6272808 38  PubMed abstract 4352834 39  PubMed abstract 14463577 40  PubMed abstract 15340161 41  PubMed abstract 4334191 42  PubMed abstract 4338630 43  PubMed abstract 4347148 44  PubMed abstract 1264228 45   Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 46  PubMed abstract 195688 47  PubMed abstract 2424570 48  PubMed abstract 2839146 49  PubMed abstract 7828531 50  PubMed abstract 9620771 51  PubMed abstract 16046320 52  PubMed abstract 16807684 53  PubMed abstract 9768693 54  PubMed abstract 10193875 55  PubMed abstract 11244459 56  PubMed abstract 12165561
Domain Name	ACTH_domain  NPP  Op_neuropeptide
Hormone Name	Met-enkephalin
Mature Hormone Sequence	YGGFM
Position of mature hormone in Pre-Hormone protein	5 Residues from position (237-241)
Receptor	Q01726    Detail in HMRbase
Gene ID	5443
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 36

HMRbase accession number	11299
Swiss-prot Accession number	P01215 (Sequence in FASTA format)
Description	Glycoprotein hormones alpha chain precursor (Anterior pituitaryglycoprotein hormones common subunit alpha) (Follitropin alpha chain)(Follicle-stimulating hormone alpha chain) (FSH-alpha) (Lutropin alphachain) (Luteinizing hormone alpha chain) (LSH-alpha) (Thyrotropinalpha chain) (Thyroid-stimulating hormone alpha chain) (TSH-alpha)(Choriogonadotropin alpha chain) (Chorionic gonadotrophin alphasubunit) (CG-alpha).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the glycoprotein hormones subunit alpha family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	N/A
Protein Length	116 Amino acids
Molecular weight	13075
References	1  PubMed abstract 481597 2  PubMed abstract 8196184 3  PubMed abstract 15489334 4  PubMed abstract 6286817 5  PubMed abstract 7462224 6  PubMed abstract 890569 7  PubMed abstract 5065401 8   Keutmann H.T., Williams R.M., Bishop W.H., Ryan R.J.; "Structure of human luteninizing hormone."; Fed. Proc. 37:1828-1828(1978). 9  PubMed abstract 1158880 10  PubMed abstract 4835135 11  PubMed abstract 1150658 12  PubMed abstract 4745444 13  PubMed abstract 6774759 14  PubMed abstract 7410374 15  PubMed abstract 1991473 16  PubMed abstract 8202136 17  PubMed abstract 8898911 18  PubMed abstract 15662415 19  PubMed abstract 481597 20  PubMed abstract 8196184 21  PubMed abstract 15489334 22  PubMed abstract 6286817 23  PubMed abstract 7462224 24  PubMed abstract 890569 25  PubMed abstract 5065401 26   Keutmann H.T., Williams R.M., Bishop W.H., Ryan R.J.; "Structure of human luteninizing hormone."; Fed. Proc. 37:1828-1828(1978). 27  PubMed abstract 1158880 28  PubMed abstract 4835135 29  PubMed abstract 1150658 30  PubMed abstract 4745444 31  PubMed abstract 6774759 32  PubMed abstract 7410374 33  PubMed abstract 1991473 34  PubMed abstract 8202136 35  PubMed abstract 8898911 36  PubMed abstract 15662415
Domain Name	Hormone_6
Hormone Name	Glycoprotein hormones alpha chain
Mature Hormone Sequence	APDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKS
Position of mature hormone in Pre-Hormone protein	92 Residues from position (25-116)
Receptor	P23945   Detail in HMRbase    P22888   Detail in HMRbase    P16473    Detail in HMRbase
Gene ID	1081
PDB ID	1DZ7   1E9J   1FL7   1HCN   1HD4   1HRP   1QFW   1XUL   1XWD
Drugpedia	wiki
Comments

Search Result - 37

HMRbase accession number	11305
Swiss-prot Accession number	P01222 (Sequence in FASTA format)
Description	Thyrotropin subunit beta precursor (Thyroid-stimulating hormonesubunit beta) (TSH-beta) (TSH-B) (Thyrotropin beta chain) (Thyrotropinalfa).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the glycoprotein hormones subunit beta family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Indispensable for the control of thyroid structure and metabolism
Protein Length	138 Amino acids
Molecular weight	15609
References	1  PubMed abstract 3839756 2  PubMed abstract 2457586 3  PubMed abstract 3234176 4  PubMed abstract 3243440 5  PubMed abstract 8196184 6  PubMed abstract 15489334 7  PubMed abstract 890569
Domain Name	Cys_knot
Hormone Name	Thyroid-stimulating hormone subunit beta (TSH-B) (Thyrotropin beta chain)
Mature Hormone Sequence	FCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYCTKPQKSY
Position of mature hormone in Pre-Hormone protein	112 Residues from position (21-132)
Receptor	P16473    Detail in HMRbase
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 38

HMRbase accession number	11308
Swiss-prot Accession number	P01225 (Sequence in FASTA format)
Description	Follitropin subunit beta precursor (Follicle-stimulating hormone betasubunit) (FSH-beta) (FSH-B) (Follitropin beta chain).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the glycoprotein hormones subunit beta family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Stimulates development of follicle and spermatogenesis in the reproductive organs
Protein Length	129 Amino acids
Molecular weight	14700
References	1  PubMed abstract 2885163 2  PubMed abstract 2494176 3  PubMed abstract 3139991 4  PubMed abstract 16554811 5  PubMed abstract 15489334 6  PubMed abstract 3151250 7  PubMed abstract 1249074 8  PubMed abstract 4835136 9  PubMed abstract 6774759 10  PubMed abstract 11501762 11  PubMed abstract 11222739 12  PubMed abstract 15662415 13  PubMed abstract 10391209 14   Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999). 15  PubMed abstract 2885163 16  PubMed abstract 2494176 17  PubMed abstract 3139991 18  PubMed abstract 16554811 19  PubMed abstract 15489334 20  PubMed abstract 3151250 21  PubMed abstract 1249074 22  PubMed abstract 4835136 23  PubMed abstract 6774759 24  PubMed abstract 11501762 25  PubMed abstract 11222739 26  PubMed abstract 15662415 27  PubMed abstract 8220432 28   Layman L.C., Lee E.-J., Peak D.B., Namnoum A.B., Vu K.V.,van Lingen B.L., Gray M.R., McDonough P.G., Reindollar R.H.,Jameson J.L.; "Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene."; N. Engl. J. Med. 337:607-611(1997). 29  PubMed abstract 9280841 30  PubMed abstract 10391209 31   Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999).
Domain Name	Cys_knot
Hormone Name	Follicle-stimulating hormone beta subunit
Mature Hormone Sequence	NSCELTNITIAIEKEECRFCISINTTWCAGYCYTRDLVYKDPARPKIQKTCTFKELVYETVRVPGCAHHADSLYTYPVATQCHCGKCDSDSTDCTVRGLGPSYCSFGEMKE
Position of mature hormone in Pre-Hormone protein	111 Residues from position (19-129)
Receptor	P23945    Detail in HMRbase
Gene ID	2488
PDB ID	1FL7   1XWD
Drugpedia	wiki
Comments

Search Result - 39

HMRbase accession number	11311
Swiss-prot Accession number	P01229 (Sequence in FASTA format)
Description	Lutropin subunit beta precursor (Luteinizing hormone subunit beta)(LSH-beta) (LSH-B) (LH-B) (Lutropin beta chain).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the glycoprotein hormones subunit beta family.
Tissue Specificity	Pituitary gland
Post translational modification	N/A
Function	Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids
Protein Length	141 Amino acids
Molecular weight	15345
References	1  PubMed abstract 6690982 2  PubMed abstract 1191677 3  PubMed abstract 4685398 4  PubMed abstract 4719207 5  PubMed abstract 1991473 6  PubMed abstract 1495492 7  PubMed abstract 1727547 8  PubMed abstract 9457942 9  PubMed abstract 9886510 10  PubMed abstract 11870227
Domain Name	Cys_knot
Hormone Name	Luteinizing hormone subunit beta (LSH-B) (LH-B)(Lutropin subunit beta)
Mature Hormone Sequence	SREPLRPWCHPINAILAVEKEGCPVCITVNTTICAGYCPTMMRVLQAVLPPLPQVVCTYRDVRFESIRLPGCPRGVDPVVSFPVALSCRCGPCRRSTSDCGGPKDHPLTCDHPQLSGLLFL
Position of mature hormone in Pre-Hormone protein	121 Residues from position (21-141)
Receptor	P22888    Detail in HMRbase
Gene ID	3972
PDB ID	1M92
Drugpedia	wiki
Comments

Search Result - 40

HMRbase accession number	11314
Swiss-prot Accession number	P01236 (Sequence in FASTA format)
Description	Prolactin precursor (PRL).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the somatotropin/prolactin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Prolactin acts primarily on the mammary gland by promoting lactation
Protein Length	227 Amino acids
Molecular weight	25876
References	1  PubMed abstract 6260780 2  PubMed abstract 6325171 3  PubMed abstract 2050267 4  PubMed abstract 15489334 5  PubMed abstract 6146607 6  PubMed abstract 9266104 7  PubMed abstract 925136 8  PubMed abstract 1126929
Domain Name	Hormone_1
Hormone Name	Prolactin
Mature Hormone Sequence	LPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC
Position of mature hormone in Pre-Hormone protein	199 Residues from position (29-227)
Receptor	P16471    Detail in HMRbase
Gene ID	5617
PDB ID	1N9D   1RW5   2Q98   3D48
Drugpedia	wiki
Comments

Search Result - 41

HMRbase accession number	11319
Swiss-prot Accession number	P01241 (Sequence in FASTA format)
Description	Somatotropin precursor (Growth hormone) (GH) (GH-N) (Pituitary growthhormone) (Growth hormone 1).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the somatotropin/prolactin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues
Protein Length	217 Amino acids
Molecular weight	24847
References	1  PubMed abstract 386281 2  PubMed abstract 377496 3  PubMed abstract 6269091 4  PubMed abstract 7169009 5  PubMed abstract 2744760 6   Gu J., Huang Q.-H., Li N., Xu S.-H., Han Z.-G., Fu G., Chen Z.; "A novel gene expressed in human pituitary."; Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. 7  PubMed abstract 10931946 8  PubMed abstract 15489334 9  PubMed abstract 3912261 10  PubMed abstract 5810834 11  PubMed abstract 5144027 12  PubMed abstract 4675454 13  PubMed abstract 5279046 14  PubMed abstract 5279528 15   Niall H.D.; "The chemistry of the human lactogenic hormones."; (In) Griffiths K. (eds.);Prolactin and carcinogenesis, Proc. fourth tenovus workshop prolactin,pp.13-20, Alpha Omega Alpha Press, Cardiff (1972). 16  PubMed abstract 7462247 17  PubMed abstract 7356479 18  PubMed abstract 7028740 19  PubMed abstract 14997482 20  PubMed abstract 10393484 21  PubMed abstract 16807684 22  PubMed abstract 3447173 23  PubMed abstract 1549776 24  PubMed abstract 7984244 25   Chantalat L., Chirgadze N.Y., Jones N., Korber F., Navaza J.,Pavlovsk A.G., Wlodawer A.; "The crystal-structure of wild-type growth-hormone at 2.5-Aresolution."; Protein Pept. Lett. 2:333-340(1995). 26  PubMed abstract 8943276 27  PubMed abstract 8552145 28   Takahashi Y., Kaji H., Okimura Y., Goji K., Abe H., Chihara K.; N. Engl. J. Med. 334:1207-1207(1996). 29  PubMed abstract 9276733 30  PubMed abstract 10391209 31   Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999). 32  PubMed abstract 11502836 33  PubMed abstract 12655557
Domain Name	Hormone_1
Hormone Name	Growth hormone (Somatotropin) (GH)
Mature Hormone Sequence	FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF
Position of mature hormone in Pre-Hormone protein	191 Residues from position (27-217)
Receptor	P10912    Detail in HMRbase
Gene ID	2688
PDB ID	1A22   1AXI   1BP3   1HGU   1HUW   1HWG   1HWH   1KF9   3HHR
Drugpedia	wiki
Comments

Search Result - 42

HMRbase accession number	11323
Swiss-prot Accession number	P01258 (Sequence in FASTA format)
Description	Calcitonin precursor [Contains: Calcitonin; Katacalcin (Calcitonincarboxyl-terminal peptide) (CCP) (PDN-21)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the calcitonin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones
Protein Length	141 Amino acids
Molecular weight	15467
References	1  PubMed abstract 6546550 2  PubMed abstract 3872459 3  PubMed abstract 3485540 4  PubMed abstract 3034287 5  PubMed abstract 2571128 6  PubMed abstract 1761559 7   Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N.,Rajkumar N., Willa H.T., Daniels M., Downing T.K., Stanaway I.B.,Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J.,Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Departmentof Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. 8  PubMed abstract 15489334 9  PubMed abstract 2408883 10  PubMed abstract 6148938 11  PubMed abstract 5760861 12  PubMed abstract 2001366 13  PubMed abstract 6132180 14  PubMed abstract 14759258
Domain Name	Calc_CGRP_IAPP
Hormone Name	Calcitonin
Mature Hormone Sequence	CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP
Position of mature hormone in Pre-Hormone protein	32 Residues from position (85-116)
Receptor	P30988    Detail in HMRbase
Gene ID	796
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 43

HMRbase accession number	11324
Swiss-prot Accession number	P01258 (Sequence in FASTA format)
Description	Calcitonin precursor [Contains: Calcitonin; Katacalcin (Calcitonincarboxyl-terminal peptide) (CCP) (PDN-21)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the calcitonin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Katacalcin is a potent plasma calcium-lowering peptide
Protein Length	141 Amino acids
Molecular weight	15467
References	1  PubMed abstract 6546550 2  PubMed abstract 3872459 3  PubMed abstract 3485540 4  PubMed abstract 3034287 5  PubMed abstract 2571128 6  PubMed abstract 1761559 7   Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N.,Rajkumar N., Willa H.T., Daniels M., Downing T.K., Stanaway I.B.,Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J.,Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Departmentof Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. 8  PubMed abstract 15489334 9  PubMed abstract 2408883 10  PubMed abstract 6148938 11  PubMed abstract 5760861 12  PubMed abstract 2001366 13  PubMed abstract 6132180 14  PubMed abstract 14759258
Domain Name	Calc_CGRP_IAPP
Hormone Name	Katacalcin
Mature Hormone Sequence	DMSSDLERDHRPHVSMPQNAN
Position of mature hormone in Pre-Hormone protein	21 Residues from position (121-141)
Receptor	P30988    Detail in HMRbase
Gene ID	796
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 44

HMRbase accession number	11328
Swiss-prot Accession number	P01270 (Sequence in FASTA format)
Description	Parathyroid hormone precursor (Parathyrin) (PTH) (Parathormone).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the parathyroid hormone family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion
Protein Length	115 Amino acids
Molecular weight	12861
References	1  PubMed abstract 6950381 2  PubMed abstract 6220408 3  PubMed abstract 15489334 4  PubMed abstract 4833516 5  PubMed abstract 15340161 6  PubMed abstract 4521809 7  PubMed abstract 728431 8   Keutmann H.T., Niall H.D., Jacobs J.W., Barling P.M., Hendy G.N.,O'Riordan J.L.H., Potts J.T. Jr.; (In) Talmadge R.V., Owen M., Parsons J.A. (eds.);Calcium-regulating hormones, pp.9-14, Excerpta Medica Foundation,Amsterdam (1975). 9  PubMed abstract 1125201 10  PubMed abstract 4474131 11  PubMed abstract 4721748 12  PubMed abstract 2069952 13  PubMed abstract 8344299 14  PubMed abstract 7797503 15  PubMed abstract 10623601 16  PubMed abstract 2212001 17  PubMed abstract 10523031
Domain Name	Parathyroid
Hormone Name	Parathyroid hormone (Parathyrin) (PTH)
Mature Hormone Sequence	SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNFVALGAPLAPRDAGSQRPRKKEDNVLVESHEKSLGEADKADVNVLTKAKSQ
Position of mature hormone in Pre-Hormone protein	84 Residues from position (32-115)
Receptor	Q03431    Detail in HMRbase
Gene ID	5741
PDB ID	1BWX   1ET1   1ET2   1FVY   1HPH   1HPY   1HTH   1ZWA   1ZWB   1ZWD   1ZWE   1ZWF   1ZWG
Drugpedia	wiki
Comments

Search Result - 45

HMRbase accession number	11329
Swiss-prot Accession number	P01275 (Sequence in FASTA format)
Description	Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide(GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1(GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-likepeptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the glucagon family.
Tissue Specificity	Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain
Post translational modification	Proglucagon is posttranslationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by posttranslational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
Function	Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life
Protein Length	180 Amino acids
Molecular weight	20909
References	1  PubMed abstract 2901414 2  PubMed abstract 3725587 3  PubMed abstract 6877358 4   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 5  PubMed abstract 15815621 6  PubMed abstract 15489334 7  PubMed abstract 11946536 8  PubMed abstract 2753890 9  PubMed abstract 8482423 10  PubMed abstract 14557443 11  PubMed abstract 14632334 12  PubMed abstract 9287128 13  PubMed abstract 12651102 14  PubMed abstract 14719035 15  PubMed abstract 12554744 16  PubMed abstract 12626323 17  PubMed abstract 10322410 18  PubMed abstract 10605628 19  PubMed abstract 9667960 20  PubMed abstract 11943215 21  PubMed abstract 12627948
Domain Name	Hormone_2
Hormone Name	Glicentin
Mature Hormone Sequence	RSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIA
Position of mature hormone in Pre-Hormone protein	69 Residues from position (21-89)
Receptor	P47871    Detail in HMRbase
Gene ID	2641
PDB ID	1BH0   1D0R   1NAU
Drugpedia	wiki
Comments

Search Result - 46

HMRbase accession number	11330
Swiss-prot Accession number	P01275 (Sequence in FASTA format)
Description	Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide(GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1(GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-likepeptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the glucagon family.
Tissue Specificity	Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain
Post translational modification	Proglucagon is posttranslationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by posttranslational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
Function	Oxyntomodulin significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness
Protein Length	180 Amino acids
Molecular weight	20909
References	1  PubMed abstract 2901414 2  PubMed abstract 3725587 3  PubMed abstract 6877358 4   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 5  PubMed abstract 15815621 6  PubMed abstract 15489334 7  PubMed abstract 11946536 8  PubMed abstract 2753890 9  PubMed abstract 8482423 10  PubMed abstract 14557443 11  PubMed abstract 14632334 12  PubMed abstract 9287128 13  PubMed abstract 12651102 14  PubMed abstract 14719035 15  PubMed abstract 12554744 16  PubMed abstract 12626323 17  PubMed abstract 10322410 18  PubMed abstract 10605628 19  PubMed abstract 9667960 20  PubMed abstract 11943215 21  PubMed abstract 12627948
Domain Name	Hormone_2
Hormone Name	Oxyntomodulin
Mature Hormone Sequence	HSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIA
Position of mature hormone in Pre-Hormone protein	37 Residues from position (53-89)
Receptor	P47871    Detail in HMRbase
Gene ID	2641
PDB ID	1BH0   1D0R   1NAU
Drugpedia	wiki
Comments

Search Result - 47

HMRbase accession number	11331
Swiss-prot Accession number	P01275 (Sequence in FASTA format)
Description	Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide(GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1(GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-likepeptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the glucagon family.
Tissue Specificity	Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain
Post translational modification	Proglucagon is posttranslationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by posttranslational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
Function	Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes
Protein Length	180 Amino acids
Molecular weight	20909
References	1  PubMed abstract 2901414 2  PubMed abstract 3725587 3  PubMed abstract 6877358 4   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 5  PubMed abstract 15815621 6  PubMed abstract 15489334 7  PubMed abstract 11946536 8  PubMed abstract 2753890 9  PubMed abstract 8482423 10  PubMed abstract 14557443 11  PubMed abstract 14632334 12  PubMed abstract 9287128 13  PubMed abstract 12651102 14  PubMed abstract 14719035 15  PubMed abstract 12554744 16  PubMed abstract 12626323 17  PubMed abstract 10322410 18  PubMed abstract 10605628 19  PubMed abstract 9667960 20  PubMed abstract 11943215 21  PubMed abstract 12627948
Domain Name	Hormone_2
Hormone Name	Glucagon
Mature Hormone Sequence	HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
Position of mature hormone in Pre-Hormone protein	29 Residues from position (53-81)
Receptor	P47871    Detail in HMRbase
Gene ID	2641
PDB ID	1BH0   1D0R   1NAU
Drugpedia	wiki
Comments

Search Result - 48

HMRbase accession number	11332
Swiss-prot Accession number	P01275 (Sequence in FASTA format)
Description	Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide(GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1(GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-likepeptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the glucagon family.
Tissue Specificity	Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain
Post translational modification	Proglucagon is posttranslationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by posttranslational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
Function	GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferaton. Inhibits beta cell apoptosis
Protein Length	180 Amino acids
Molecular weight	20909
References	1  PubMed abstract 2901414 2  PubMed abstract 3725587 3  PubMed abstract 6877358 4   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 5  PubMed abstract 15815621 6  PubMed abstract 15489334 7  PubMed abstract 11946536 8  PubMed abstract 2753890 9  PubMed abstract 8482423 10  PubMed abstract 14557443 11  PubMed abstract 14632334 12  PubMed abstract 9287128 13  PubMed abstract 12651102 14  PubMed abstract 14719035 15  PubMed abstract 12554744 16  PubMed abstract 12626323 17  PubMed abstract 10322410 18  PubMed abstract 10605628 19  PubMed abstract 9667960 20  PubMed abstract 11943215 21  PubMed abstract 12627948
Domain Name	Hormone_2
Hormone Name	Glucagon-like peptide 1
Mature Hormone Sequence	HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG
Position of mature hormone in Pre-Hormone protein	37 Residues from position (92-128)
Receptor	P47871    Detail in HMRbase
Gene ID	2641
PDB ID	1BH0   1D0R   1NAU
Drugpedia	wiki
Comments

Search Result - 49

HMRbase accession number	11333
Swiss-prot Accession number	P01275 (Sequence in FASTA format)
Description	Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide(GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1(GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-likepeptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the glucagon family.
Tissue Specificity	Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain
Post translational modification	Proglucagon is posttranslationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by posttranslational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
Function	GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability
Protein Length	180 Amino acids
Molecular weight	20909
References	1  PubMed abstract 2901414 2  PubMed abstract 3725587 3  PubMed abstract 6877358 4   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 5  PubMed abstract 15815621 6  PubMed abstract 15489334 7  PubMed abstract 11946536 8  PubMed abstract 2753890 9  PubMed abstract 8482423 10  PubMed abstract 14557443 11  PubMed abstract 14632334 12  PubMed abstract 9287128 13  PubMed abstract 12651102 14  PubMed abstract 14719035 15  PubMed abstract 12554744 16  PubMed abstract 12626323 17  PubMed abstract 10322410 18  PubMed abstract 10605628 19  PubMed abstract 9667960 20  PubMed abstract 11943215 21  PubMed abstract 12627948
Domain Name	Hormone_2
Hormone Name	Glucagon-like peptide 2
Mature Hormone Sequence	HADGSFSDEMNTILDNLAARDFINWLIQTKITD
Position of mature hormone in Pre-Hormone protein	33 Residues from position (146-178)
Receptor	P47871    Detail in HMRbase
Gene ID	2641
PDB ID	1BH0   1D0R   1NAU
Drugpedia	wiki
Comments

Search Result - 50

HMRbase accession number	11334
Swiss-prot Accession number	P01286 (Sequence in FASTA format)
Description	Somatoliberin precursor (Growth hormone-releasing factor) (GRF)(Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin)(Sermorelin).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the glucagon family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone
Protein Length	108 Amino acids
Molecular weight	12447
References	1  PubMed abstract 6192430 2  PubMed abstract 3918305 3  PubMed abstract 11780052 4  PubMed abstract 15489334 5  PubMed abstract 6415488 6  PubMed abstract 6812220 7  PubMed abstract 2854259 8  PubMed abstract 3029387
Domain Name	Hormone_2
Hormone Name	Growth hormone-releasing factor (GRF) (Growth hormone-releasing hormone) (GHRH)
Mature Hormone Sequence	YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL
Position of mature hormone in Pre-Hormone protein	44 Residues from position (32-75)
Receptor	Q02643    Detail in HMRbase
Gene ID	2691
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 51

HMRbase accession number	11336
Swiss-prot Accession number	P01308 (Sequence in FASTA format)
Description	Insulin precursor [Contains: Insulin B chain; Insulin A chain].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver
Protein Length	110 Amino acids
Molecular weight	11981
References	1  PubMed abstract 6243748 2  PubMed abstract 6248962 3  PubMed abstract 503234 4  PubMed abstract 6927840 5  PubMed abstract 8358440 6   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. 7  PubMed abstract 15489334 8   Fajardy I.I., Weill J.J., Stuckens C.C., Danze P.M.P.; "Description of a novel RFLP diallelic polymorphism (-127 BsgI C/G)within the 5' region of insulin gene."; Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases. 9  PubMed abstract 14426955 10  PubMed abstract 5101771 11  PubMed abstract 5560404 12  PubMed abstract 4443293 13  PubMed abstract 4803504 14  PubMed abstract 4698555 15  PubMed abstract 4698553 16  PubMed abstract 6312455 17  PubMed abstract 6424111 18  PubMed abstract 3470784 19  PubMed abstract 3537011 20  PubMed abstract 2196279 21  PubMed abstract 4019786 22  PubMed abstract 1601997 23  PubMed abstract 2271664 24  PubMed abstract 2036420 25  PubMed abstract 1646635 26  PubMed abstract 1433291 27  PubMed abstract 8421693 28  PubMed abstract 9235985
Domain Name	Insulin
Hormone Name	Insulin B chain
Mature Hormone Sequence	FVNQHLCGSHLVEALYLVCGERGFFYTPKT
Position of mature hormone in Pre-Hormone protein	30 Residues from position (25-54)
Receptor	P06213    Detail in HMRbase
Gene ID	3630
PDB ID	1A7F   1AI0   1AIY   1B9E   1BEN   1EFE   1EV3   1EV6   1EVR   1FU2   1FUB   1G7A   1G7B   1GUJ   1HIQ   1HIS   1HIT   1HLS   1HTV   1HUI   1IOG   1IOH   1J73   1JCA   1JCO   1K3M   1KMF   1LKQ   1LPH   1MHI   1MHJ   1MSO   1OS3   1OS4   1QIY   1QIZ   1QJ0   1RWE   1SF1   1SJT   1SJU   1T0C   1T1K   1T1P   1T1Q   1TRZ   1TYL   1TYM   1UZ9   1VKT   1W8P
Drugpedia	wiki
Comments

Search Result - 52

HMRbase accession number	11337
Swiss-prot Accession number	P01308 (Sequence in FASTA format)
Description	Insulin precursor [Contains: Insulin B chain; Insulin A chain].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver
Protein Length	110 Amino acids
Molecular weight	11981
References	1  PubMed abstract 6243748 2  PubMed abstract 6248962 3  PubMed abstract 503234 4  PubMed abstract 6927840 5  PubMed abstract 8358440 6   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. 7  PubMed abstract 15489334 8   Fajardy I.I., Weill J.J., Stuckens C.C., Danze P.M.P.; "Description of a novel RFLP diallelic polymorphism (-127 BsgI C/G)within the 5' region of insulin gene."; Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases. 9  PubMed abstract 14426955 10  PubMed abstract 5101771 11  PubMed abstract 5560404 12  PubMed abstract 4443293 13  PubMed abstract 4803504 14  PubMed abstract 4698555 15  PubMed abstract 4698553 16  PubMed abstract 6312455 17  PubMed abstract 6424111 18  PubMed abstract 3470784 19  PubMed abstract 3537011 20  PubMed abstract 2196279 21  PubMed abstract 4019786 22  PubMed abstract 1601997 23  PubMed abstract 2271664 24  PubMed abstract 2036420 25  PubMed abstract 1646635 26  PubMed abstract 1433291 27  PubMed abstract 8421693 28  PubMed abstract 9235985
Domain Name	Insulin
Hormone Name	Insulin A chain
Mature Hormone Sequence	GIVEQCCTSICSLYQLENYCN
Position of mature hormone in Pre-Hormone protein	21 Residues from position (90-110)
Receptor	P06213    Detail in HMRbase
Gene ID	3630
PDB ID	1A7F   1AI0   1AIY   1B9E   1BEN   1EFE   1EV3   1EV6   1EVR   1FU2   1FUB   1G7A   1G7B   1GUJ   1HIQ   1HIS   1HIT   1HLS   1HTV   1HUI   1IOG   1IOH   1J73   1JCA   1JCO   1K3M   1KMF   1LKQ   1LPH   1MHI   1MHJ   1MSO   1OS3   1OS4   1QIY   1QIZ   1QJ0   1RWE   1SF1   1SJT   1SJU   1T0C   1T1K   1T1P   1T1Q   1TRZ   1TYL   1TYM   1UZ9   1VKT   1W8P
Drugpedia	wiki
Comments

Search Result - 53

HMRbase accession number	11344
Swiss-prot Accession number	P01350 (Sequence in FASTA format)
Description	Gastrin precursor [Contains: Gastrin-71 (Component I); Gastrin-52(G52); Big gastrin (Gastrin-34) (G34) (Component II); Gastrin(Gastrin-17) (G17) (Component III); Gastrin-14 (G14); Gastrin-6 (G6)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the gastrin/cholecystokinin family.
Tissue Specificity	N/A
Post translational modification	Two different processing pathways probably exist in antral G- cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation of Tyr-87 blocks peptide degradation and enhances activity.
Function	Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine
Protein Length	101 Amino acids
Molecular weight	11394
References	1  PubMed abstract 3034736 2  PubMed abstract 6087340 3  PubMed abstract 6324077 4  PubMed abstract 6574456 5  PubMed abstract 6322186 6  PubMed abstract 6689486 7  PubMed abstract 15489334 8  PubMed abstract 8055952 9  PubMed abstract 5921183 10  PubMed abstract 2730647 11  PubMed abstract 5822140 12  PubMed abstract 7530658 13  PubMed abstract 11052986
Domain Name	Gastrin
Hormone Name	Gastrin-71
Mature Hormone Sequence	SWKPRSQQPDAPLGTGANRDLELPWLEQQGPASHHRRQLGPQGPPHLVADPSKKQGPWLEEEEEAYGWMDF
Position of mature hormone in Pre-Hormone protein	71 Residues from position (22-92)
Receptor	P32239    Detail in HMRbase
Gene ID	2520
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 54

HMRbase accession number	11345
Swiss-prot Accession number	P01350 (Sequence in FASTA format)
Description	Gastrin precursor [Contains: Gastrin-71 (Component I); Gastrin-52(G52); Big gastrin (Gastrin-34) (G34) (Component II); Gastrin(Gastrin-17) (G17) (Component III); Gastrin-14 (G14); Gastrin-6 (G6)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the gastrin/cholecystokinin family.
Tissue Specificity	N/A
Post translational modification	Two different processing pathways probably exist in antral G- cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation of Tyr-87 blocks peptide degradation and enhances activity.
Function	Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine
Protein Length	101 Amino acids
Molecular weight	11394
References	1  PubMed abstract 3034736 2  PubMed abstract 6087340 3  PubMed abstract 6324077 4  PubMed abstract 6574456 5  PubMed abstract 6322186 6  PubMed abstract 6689486 7  PubMed abstract 15489334 8  PubMed abstract 8055952 9  PubMed abstract 5921183 10  PubMed abstract 2730647 11  PubMed abstract 5822140 12  PubMed abstract 7530658 13  PubMed abstract 11052986
Domain Name	Gastrin
Hormone Name	Gastrin-52
Mature Hormone Sequence	DLELPWLEQQGPASHHRRQLGPQGPPHLVADPSKKQGPWLEEEEEAYGWMDF
Position of mature hormone in Pre-Hormone protein	52 Residues from position (41-92)
Receptor	P32239    Detail in HMRbase
Gene ID	2520
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 55

HMRbase accession number	11346
Swiss-prot Accession number	P01350 (Sequence in FASTA format)
Description	Gastrin precursor [Contains: Gastrin-71 (Component I); Gastrin-52(G52); Big gastrin (Gastrin-34) (G34) (Component II); Gastrin(Gastrin-17) (G17) (Component III); Gastrin-14 (G14); Gastrin-6 (G6)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the gastrin/cholecystokinin family.
Tissue Specificity	N/A
Post translational modification	Two different processing pathways probably exist in antral G- cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation of Tyr-87 blocks peptide degradation and enhances activity.
Function	Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine
Protein Length	101 Amino acids
Molecular weight	11394
References	1  PubMed abstract 3034736 2  PubMed abstract 6087340 3  PubMed abstract 6324077 4  PubMed abstract 6574456 5  PubMed abstract 6322186 6  PubMed abstract 6689486 7  PubMed abstract 15489334 8  PubMed abstract 8055952 9  PubMed abstract 5921183 10  PubMed abstract 2730647 11  PubMed abstract 5822140 12  PubMed abstract 7530658 13  PubMed abstract 11052986
Domain Name	Gastrin
Hormone Name	Big gastrin
Mature Hormone Sequence	QLGPQGPPHLVADPSKKQGPWLEEEEEAYGWMDF
Position of mature hormone in Pre-Hormone protein	34 Residues from position (59-92)
Receptor	P32239    Detail in HMRbase
Gene ID	2520
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 56

HMRbase accession number	11347
Swiss-prot Accession number	P01350 (Sequence in FASTA format)
Description	Gastrin precursor [Contains: Gastrin-71 (Component I); Gastrin-52(G52); Big gastrin (Gastrin-34) (G34) (Component II); Gastrin(Gastrin-17) (G17) (Component III); Gastrin-14 (G14); Gastrin-6 (G6)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the gastrin/cholecystokinin family.
Tissue Specificity	N/A
Post translational modification	Two different processing pathways probably exist in antral G- cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation of Tyr-87 blocks peptide degradation and enhances activity.
Function	Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine
Protein Length	101 Amino acids
Molecular weight	11394
References	1  PubMed abstract 3034736 2  PubMed abstract 6087340 3  PubMed abstract 6324077 4  PubMed abstract 6574456 5  PubMed abstract 6322186 6  PubMed abstract 6689486 7  PubMed abstract 15489334 8  PubMed abstract 8055952 9  PubMed abstract 5921183 10  PubMed abstract 2730647 11  PubMed abstract 5822140 12  PubMed abstract 7530658 13  PubMed abstract 11052986
Domain Name	Gastrin
Hormone Name	Gastrin
Mature Hormone Sequence	QGPWLEEEEEAYGWMDF
Position of mature hormone in Pre-Hormone protein	17 Residues from position (76-92)
Receptor	P32239    Detail in HMRbase
Gene ID	2520
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 57

HMRbase accession number	11348
Swiss-prot Accession number	P01350 (Sequence in FASTA format)
Description	Gastrin precursor [Contains: Gastrin-71 (Component I); Gastrin-52(G52); Big gastrin (Gastrin-34) (G34) (Component II); Gastrin(Gastrin-17) (G17) (Component III); Gastrin-14 (G14); Gastrin-6 (G6)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the gastrin/cholecystokinin family.
Tissue Specificity	N/A
Post translational modification	Two different processing pathways probably exist in antral G- cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation of Tyr-87 blocks peptide degradation and enhances activity.
Function	Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine
Protein Length	101 Amino acids
Molecular weight	11394
References	1  PubMed abstract 3034736 2  PubMed abstract 6087340 3  PubMed abstract 6324077 4  PubMed abstract 6574456 5  PubMed abstract 6322186 6  PubMed abstract 6689486 7  PubMed abstract 15489334 8  PubMed abstract 8055952 9  PubMed abstract 5921183 10  PubMed abstract 2730647 11  PubMed abstract 5822140 12  PubMed abstract 7530658 13  PubMed abstract 11052986
Domain Name	Gastrin
Hormone Name	Gastrin-14
Mature Hormone Sequence	WLEEEEEAYGWMDF
Position of mature hormone in Pre-Hormone protein	14 Residues from position (79-92)
Receptor	P32239    Detail in HMRbase
Gene ID	2520
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 58

HMRbase accession number	11349
Swiss-prot Accession number	P01350 (Sequence in FASTA format)
Description	Gastrin precursor [Contains: Gastrin-71 (Component I); Gastrin-52(G52); Big gastrin (Gastrin-34) (G34) (Component II); Gastrin(Gastrin-17) (G17) (Component III); Gastrin-14 (G14); Gastrin-6 (G6)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the gastrin/cholecystokinin family.
Tissue Specificity	N/A
Post translational modification	Two different processing pathways probably exist in antral G- cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation of Tyr-87 blocks peptide degradation and enhances activity.
Function	Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine
Protein Length	101 Amino acids
Molecular weight	11394
References	1  PubMed abstract 3034736 2  PubMed abstract 6087340 3  PubMed abstract 6324077 4  PubMed abstract 6574456 5  PubMed abstract 6322186 6  PubMed abstract 6689486 7  PubMed abstract 15489334 8  PubMed abstract 8055952 9  PubMed abstract 5921183 10  PubMed abstract 2730647 11  PubMed abstract 5822140 12  PubMed abstract 7530658 13  PubMed abstract 11052986
Domain Name	Gastrin
Hormone Name	Gastrin-6
Mature Hormone Sequence	YGWMDF
Position of mature hormone in Pre-Hormone protein	6 Residues from position (87-92)
Receptor	P32239    Detail in HMRbase
Gene ID	2520
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 59

HMRbase accession number	11360
Swiss-prot Accession number	P03971 (Sequence in FASTA format)
Description	Muellerian-inhibiting factor precursor (MIS) (Anti-Muellerian hormone)(AMH) (Muellerian-inhibiting substance).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the TGF-beta family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin
Protein Length	560 Amino acids
Molecular weight	59193
References	1  PubMed abstract 3754790 2  PubMed abstract 15057824 3  PubMed abstract 1483695 4  PubMed abstract 8162013 5  PubMed abstract 8872466
Domain Name	N/A
Hormone Name	Muellerian-inhibiting factor
Mature Hormone Sequence	RAEEPAVGTSGLIFREDLDWPPGIPQEPLCLVALGGDSNGSSSPLRVVGALSAYEQAFLGAVQRARWGPRDLATFGVCNTGDRQAALPSLRRLGAWLRDPGGQRLVVLHLEEVTWEPTPSLRFQEPPPGGAGPPELALLVLYPGPGPEVTVTRAGLPGAQSLCPSRDTRYLVLAVDRPAGAWRGSGLALTLQPRGEDSRLSTARLQALLFGDDHRCFTRMTPALLLLPRSEPAPLPAHGQLDTVPFPPPRPSAELEESPPSADPFLETLTRLVRALRVPPARASAPRLALDPDALAGFPQGLVNLSDPAALERLLDGEEPLLLLLRPTAATTGDPAPLHDPTSAPWATALARRVAAELQAAAAELRSLPGLPPATAPLLARLLALCPGGPGGLGDPLRALLLLKALQGLRVEWRGRDPRGPGRAQRSAGATAADGPCALRELSVDLRAERSVLIPETYQANNCQGVCGWPQSDRNPRYGNHVVLLLKMQARGAALARPPCCVPTAYAGKLLISLSEERISAHHVPNMVATECGCR
Position of mature hormone in Pre-Hormone protein	535 Residues from position (26-560)
Receptor	Q16671    Detail in HMRbase
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 60

HMRbase accession number	11362
Swiss-prot Accession number	P04090 (Sequence in FASTA format)
Description	Prorelaxin H2 precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	Isoform 1 expressed in the ovary during pregnancy. Also expressed in placenta, decidua and prostate. Isoform 2 relatively abundant in placenta, much lower abundance in the prostate gland. Not detected in the ovary
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix
Protein Length	185 Amino acids
Molecular weight	21043
References	1  PubMed abstract 6548702 2  PubMed abstract 15164053 3  PubMed abstract 15489334 4  PubMed abstract 8735594 5  PubMed abstract 10601981 6  PubMed abstract 1572287 7  PubMed abstract 2076464 8  PubMed abstract 2040595 9  PubMed abstract 1656049
Domain Name	Insulin
Hormone Name	Relaxin B chain
Mature Hormone Sequence	DSWMEEVIKLCGRELVRAQIAICGMSTWS
Position of mature hormone in Pre-Hormone protein	29 Residues from position (25-53)
Receptor	Q9HBX9   Detail in HMRbase    Q8WXD0    Detail in HMRbase
Gene ID	6019
PDB ID	6RLX
Drugpedia	wiki
Comments

Search Result - 61

HMRbase accession number	11363
Swiss-prot Accession number	P04090 (Sequence in FASTA format)
Description	Prorelaxin H2 precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	Isoform 1 expressed in the ovary during pregnancy. Also expressed in placenta, decidua and prostate. Isoform 2 relatively abundant in placenta, much lower abundance in the prostate gland. Not detected in the ovary
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix
Protein Length	185 Amino acids
Molecular weight	21043
References	1  PubMed abstract 6548702 2  PubMed abstract 15164053 3  PubMed abstract 15489334 4  PubMed abstract 8735594 5  PubMed abstract 10601981 6  PubMed abstract 1572287 7  PubMed abstract 2076464 8  PubMed abstract 2040595 9  PubMed abstract 1656049
Domain Name	Insulin
Hormone Name	Relaxin A chain
Mature Hormone Sequence	QLYSALANKCCHVGCTKRSLARFC
Position of mature hormone in Pre-Hormone protein	24 Residues from position (162-185)
Receptor	Q9HBX9   Detail in HMRbase    Q8WXD0    Detail in HMRbase
Gene ID	6019
PDB ID	6RLX
Drugpedia	wiki
Comments

Search Result - 62

HMRbase accession number	11369
Swiss-prot Accession number	P04808 (Sequence in FASTA format)
Description	Prorelaxin H1 precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	Prostate. Not expressed in placenta, decidua or ovary
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix
Protein Length	185 Amino acids
Molecular weight	21146
References	1  PubMed abstract 6548702 2  PubMed abstract 6298628 3  PubMed abstract 15164053 4  PubMed abstract 15489334 5  PubMed abstract 8735594 6  PubMed abstract 10601981
Domain Name	Insulin
Hormone Name	Relaxin B chain
Mature Hormone Sequence	VAAKWKDDVIKLCGRELVRAQIAICGMSTWS
Position of mature hormone in Pre-Hormone protein	31 Residues from position (23-53)
Receptor	Q9HBX9   Detail in HMRbase    Q8WXD0    Detail in HMRbase
Gene ID	6013
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 63

HMRbase accession number	11370
Swiss-prot Accession number	P04808 (Sequence in FASTA format)
Description	Prorelaxin H1 precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	Prostate. Not expressed in placenta, decidua or ovary
Post translational modification	N/A
Function	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix
Protein Length	185 Amino acids
Molecular weight	21146
References	1  PubMed abstract 6548702 2  PubMed abstract 6298628 3  PubMed abstract 15164053 4  PubMed abstract 15489334 5  PubMed abstract 8735594 6  PubMed abstract 10601981
Domain Name	Insulin
Hormone Name	Relaxin A chain
Mature Hormone Sequence	PYVALFEKCCLIGCTKRSLAKYC
Position of mature hormone in Pre-Hormone protein	23 Residues from position (163-185)
Receptor	Q9HBX9   Detail in HMRbase    Q8WXD0    Detail in HMRbase
Gene ID	6013
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 64

HMRbase accession number	11372
Swiss-prot Accession number	P06307 (Sequence in FASTA format)
Description	Cholecystokinins precursor (CCK) [Contains: Cholecystokinin 58(CCK58); Cholecystokinin 39 (CCK39); Cholecystokinin 33 (CCK33);Cholecystokinin 12 (CCK12); Cholecystokinin 8 (CCK8)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the gastrin/cholecystokinin family.
Tissue Specificity	N/A
Post translational modification	The precursor cleaved by enzymes to produce a number of active cholecystokinins.
Function	This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion
Protein Length	115 Amino acids
Molecular weight	12669
References	1  PubMed abstract 3856870 2   Kato K., Takahashi Y., Matsubara K.; "Molecular cloning of the human cholecystokinin gene."; Ann. N. Y. Acad. Sci. 448:613-615(1985). 3   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 4   Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N.,Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S.,Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Departmentof Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. 5  PubMed abstract 15489334 6  PubMed abstract 11076522
Domain Name	Gastrin
Hormone Name	Cholecystokinin
Mature Hormone Sequence	QPVPPADPAGSGLQRAEEAPRRQLRVSQRTDGESRAHLGALLARYIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDFGRRSAEEYEYPS
Position of mature hormone in Pre-Hormone protein	95 Residues from position (21-115)
Receptor	P32239   Detail in HMRbase    P32238    Detail in HMRbase
Gene ID	885
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 65

HMRbase accession number	11373
Swiss-prot Accession number	P06307 (Sequence in FASTA format)
Description	Cholecystokinins precursor (CCK) [Contains: Cholecystokinin 58(CCK58); Cholecystokinin 39 (CCK39); Cholecystokinin 33 (CCK33);Cholecystokinin 12 (CCK12); Cholecystokinin 8 (CCK8)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the gastrin/cholecystokinin family.
Tissue Specificity	N/A
Post translational modification	The precursor cleaved by enzymes to produce a number of active cholecystokinins.
Function	This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion
Protein Length	115 Amino acids
Molecular weight	12669
References	1  PubMed abstract 3856870 2   Kato K., Takahashi Y., Matsubara K.; "Molecular cloning of the human cholecystokinin gene."; Ann. N. Y. Acad. Sci. 448:613-615(1985). 3   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 4   Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N.,Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S.,Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Departmentof Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. 5  PubMed abstract 15489334 6  PubMed abstract 11076522
Domain Name	Gastrin
Hormone Name	Cholecystokinin-58
Mature Hormone Sequence	VSQRTDGESRAHLGALLARYIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDF
Position of mature hormone in Pre-Hormone protein	58 Residues from position (46-103)
Receptor	P32239   Detail in HMRbase    P32238    Detail in HMRbase
Gene ID	885
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 66

HMRbase accession number	11374
Swiss-prot Accession number	P06307 (Sequence in FASTA format)
Description	Cholecystokinins precursor (CCK) [Contains: Cholecystokinin 58(CCK58); Cholecystokinin 39 (CCK39); Cholecystokinin 33 (CCK33);Cholecystokinin 12 (CCK12); Cholecystokinin 8 (CCK8)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the gastrin/cholecystokinin family.
Tissue Specificity	N/A
Post translational modification	The precursor cleaved by enzymes to produce a number of active cholecystokinins.
Function	This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion
Protein Length	115 Amino acids
Molecular weight	12669
References	1  PubMed abstract 3856870 2   Kato K., Takahashi Y., Matsubara K.; "Molecular cloning of the human cholecystokinin gene."; Ann. N. Y. Acad. Sci. 448:613-615(1985). 3   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 4   Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N.,Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S.,Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Departmentof Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. 5  PubMed abstract 15489334 6  PubMed abstract 11076522
Domain Name	Gastrin
Hormone Name	Cholecystokinin-39
Mature Hormone Sequence	YIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDF
Position of mature hormone in Pre-Hormone protein	39 Residues from position (65-103)
Receptor	P32239   Detail in HMRbase    P32238    Detail in HMRbase
Gene ID	885
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 67

HMRbase accession number	11375
Swiss-prot Accession number	P06307 (Sequence in FASTA format)
Description	Cholecystokinins precursor (CCK) [Contains: Cholecystokinin 58(CCK58); Cholecystokinin 39 (CCK39); Cholecystokinin 33 (CCK33);Cholecystokinin 12 (CCK12); Cholecystokinin 8 (CCK8)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the gastrin/cholecystokinin family.
Tissue Specificity	N/A
Post translational modification	The precursor cleaved by enzymes to produce a number of active cholecystokinins.
Function	This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion
Protein Length	115 Amino acids
Molecular weight	12669
References	1  PubMed abstract 3856870 2   Kato K., Takahashi Y., Matsubara K.; "Molecular cloning of the human cholecystokinin gene."; Ann. N. Y. Acad. Sci. 448:613-615(1985). 3   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 4   Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N.,Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S.,Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Departmentof Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. 5  PubMed abstract 15489334 6  PubMed abstract 11076522
Domain Name	Gastrin
Hormone Name	Cholecystokinin-33
Mature Hormone Sequence	KAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDF
Position of mature hormone in Pre-Hormone protein	33 Residues from position (71-103)
Receptor	P32239   Detail in HMRbase    P32238    Detail in HMRbase
Gene ID	885
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 68

HMRbase accession number	11376
Swiss-prot Accession number	P06307 (Sequence in FASTA format)
Description	Cholecystokinins precursor (CCK) [Contains: Cholecystokinin 58(CCK58); Cholecystokinin 39 (CCK39); Cholecystokinin 33 (CCK33);Cholecystokinin 12 (CCK12); Cholecystokinin 8 (CCK8)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the gastrin/cholecystokinin family.
Tissue Specificity	N/A
Post translational modification	The precursor cleaved by enzymes to produce a number of active cholecystokinins.
Function	This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion
Protein Length	115 Amino acids
Molecular weight	12669
References	1  PubMed abstract 3856870 2   Kato K., Takahashi Y., Matsubara K.; "Molecular cloning of the human cholecystokinin gene."; Ann. N. Y. Acad. Sci. 448:613-615(1985). 3   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 4   Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N.,Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S.,Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Departmentof Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. 5  PubMed abstract 15489334 6  PubMed abstract 11076522
Domain Name	Gastrin
Hormone Name	Cholecystokinin-8
Mature Hormone Sequence	DYMGWMDF
Position of mature hormone in Pre-Hormone protein	8 Residues from position (96-103)
Receptor	P32239   Detail in HMRbase    P32238    Detail in HMRbase
Gene ID	885
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 69

HMRbase accession number	11377
Swiss-prot Accession number	P06850 (Sequence in FASTA format)
Description	Corticoliberin precursor (Corticotropin-releasing factor) (CRF)(Corticotropin-releasing hormone).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	This hormone from hypothalamus regulates the release of corticotropin from pituitary gland
Protein Length	196 Amino acids
Molecular weight	21422
References	1  PubMed abstract 6605851 2  PubMed abstract 2783917 3   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 4  PubMed abstract 15489334 5  PubMed abstract 3262120 6  PubMed abstract 8386360
Domain Name	CRF
Hormone Name	Corticoliberin
Mature Hormone Sequence	SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII
Position of mature hormone in Pre-Hormone protein	41 Residues from position (154-194)
Receptor	P34998   Detail in HMRbase    Q13324    Detail in HMRbase
Gene ID	1392
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 70

HMRbase accession number	11387
Swiss-prot Accession number	P07492 (Sequence in FASTA format)
Description	Gastrin-releasing peptide precursor (GRP) [Contains: Neuromedin-C(GRP-10)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the bombesin/neuromedin-B/ranatensin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	GRP stimulates gastrin release as well as other gastrointestinal hormones
Protein Length	148 Amino acids
Molecular weight	16144
References	1  PubMed abstract 3001723 2  PubMed abstract 3211139 3  PubMed abstract 3003116 4  PubMed abstract 15489334
Domain Name	Bombesin
Hormone Name	Gastrin-releasing peptide
Mature Hormone Sequence	VPLPAGGGTVLTKMYPRGNHWAVGHLM
Position of mature hormone in Pre-Hormone protein	27 Residues from position (24-50)
Receptor	P30550    Detail in HMRbase
Gene ID	2922
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 71

HMRbase accession number	11388
Swiss-prot Accession number	P07492 (Sequence in FASTA format)
Description	Gastrin-releasing peptide precursor (GRP) [Contains: Neuromedin-C(GRP-10)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the bombesin/neuromedin-B/ranatensin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	It is also a bombesin-like peptide, which causes potent stimulation of smooth muscle of uterus.
Protein Length	148 Amino acids
Molecular weight	16144
References	1  PubMed abstract 3001723 2  PubMed abstract 3211139 3  PubMed abstract 3003116 4  PubMed abstract 15489334
Domain Name	Bombesin
Hormone Name	Neuromedin-C
Mature Hormone Sequence	GNHWAVGHLM
Position of mature hormone in Pre-Hormone protein	10 Residues from position (41-50)
Receptor	P30550    Detail in HMRbase
Gene ID	2922
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 72

HMRbase accession number	11396
Swiss-prot Accession number	P09683 (Sequence in FASTA format)
Description	Secretin precursor.
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the glucagon family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach
Protein Length	121 Amino acids
Molecular weight	13016
References	1  PubMed abstract 11060443 2   Carlquist M., Joernvall H., Forssmann W.-G., Thulin L., Johansson C.,Mutt V.; "Human secretin is not identical to the porcine/bovine hormone."; IRCS Med. Sci. 13:217-218(1985).
Domain Name	Hormone_2
Hormone Name	Secretin
Mature Hormone Sequence	HSDGTFTSELSRLREGARLQRLLQGLV
Position of mature hormone in Pre-Hormone protein	27 Residues from position (28-54)
Receptor	Q8IV17   Detail in HMRbase    P47872    Detail in HMRbase
Gene ID	6343
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 73

HMRbase accession number	11423
Swiss-prot Accession number	P20382 (Sequence in FASTA format)
Description	Pro-MCH precursor [Contains: Neuropeptide-glycine-glutamic acid (NGE)(Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI)(Neuropeptide E-I); Melanin-concentrating hormone (MCH)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the melanin-concentrating hormone family.
Tissue Specificity	Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly
Post translational modification	Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. MCH is a cyclic peptide.
Function	N/A
Protein Length	165 Amino acids
Molecular weight	18723
References	1  PubMed abstract 2149166 2  PubMed abstract 8326825 3  PubMed abstract 10037747 4  PubMed abstract 9191099
Domain Name	Pro-MCH
Hormone Name	Neuropeptide-glutamic acid-isoleucine
Mature Hormone Sequence	EIGDEENSAKFPI
Position of mature hormone in Pre-Hormone protein	13 Residues from position (131-143)
Receptor	Q99705   Detail in HMRbase    Q969V1    Detail in HMRbase
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 74

HMRbase accession number	11424
Swiss-prot Accession number	P20382 (Sequence in FASTA format)
Description	Pro-MCH precursor [Contains: Neuropeptide-glycine-glutamic acid (NGE)(Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI)(Neuropeptide E-I); Melanin-concentrating hormone (MCH)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the melanin-concentrating hormone family.
Tissue Specificity	Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly
Post translational modification	Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. MCH is a cyclic peptide.
Function	MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation
Protein Length	165 Amino acids
Molecular weight	18723
References	1  PubMed abstract 2149166 2  PubMed abstract 8326825 3  PubMed abstract 10037747 4  PubMed abstract 9191099
Domain Name	Pro-MCH
Hormone Name	Melanin-concentrating hormone
Mature Hormone Sequence	FPIGRRDFDMLRCMLGRVYRPCWQV
Position of mature hormone in Pre-Hormone protein	19 Residues from position (147-165)
Receptor	Q99705   Detail in HMRbase    Q969V1    Detail in HMRbase
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 75

HMRbase accession number	11425
Swiss-prot Accession number	P20396 (Sequence in FASTA format)
Description	Thyroliberin precursor [Contains: Prothyroliberin; Thyroliberin(Thyrotropin-releasing hormone) (TRH) (Thyrotropin-releasing factor)(TRF) (TSH-releasing factor) (Protirelin)].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the TRH family.
Tissue Specificity	Hypothalamus
Post translational modification	N/A
Function	Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems
Protein Length	242 Amino acids
Molecular weight	27404
References	1  PubMed abstract 2126343 2  PubMed abstract 15489334
Domain Name	TRH
Hormone Name	Thyroliberin
Mature Hormone Sequence	QHP
Position of mature hormone in Pre-Hormone protein	3 Residues from position (84-86)
Receptor	P34981    Detail in HMRbase
Gene ID	7200
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 76

HMRbase accession number	11489
Swiss-prot Accession number	P61278 (Sequence in FASTA format)
Description	Somatostatin precursor (Growth hormone release-inhibiting factor)[Contains: Somatostatin-28; Somatostatin-14].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the somatostatin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Somatostatin inhibits the release of somatotropin
Protein Length	116 Amino acids
Molecular weight	12736
References	1  PubMed abstract 6126875 2  PubMed abstract 6142531 3  PubMed abstract 15489334 4  PubMed abstract 6126875 5  PubMed abstract 6142531 6  PubMed abstract 15489334
Domain Name	Somatostatin
Hormone Name	Somatostatin-28
Mature Hormone Sequence	SANSNPAMAPRERKAGCKNFFWKTFTSC
Position of mature hormone in Pre-Hormone protein	28 Residues from position (89-116)
Receptor	P30872   Detail in HMRbase    P30874   Detail in HMRbase    P32745   Detail in HMRbase    P35346    Detail in HMRbase
Gene ID	6750
PDB ID	1P2W
Drugpedia	wiki
Comments

Search Result - 77

HMRbase accession number	11490
Swiss-prot Accession number	P61278 (Sequence in FASTA format)
Description	Somatostatin precursor (Growth hormone release-inhibiting factor)[Contains: Somatostatin-28; Somatostatin-14].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the somatostatin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Somatostatin inhibits the release of somatotropin
Protein Length	116 Amino acids
Molecular weight	12736
References	1  PubMed abstract 6126875 2  PubMed abstract 6142531 3  PubMed abstract 15489334 4  PubMed abstract 6126875 5  PubMed abstract 6142531 6  PubMed abstract 15489334
Domain Name	Somatostatin
Hormone Name	Somatostatin-14
Mature Hormone Sequence	AGCKNFFWKTFTSC
Position of mature hormone in Pre-Hormone protein	14 Residues from position (103-116)
Receptor	P30872   Detail in HMRbase    P30874   Detail in HMRbase    P32745   Detail in HMRbase    P35346    Detail in HMRbase
Gene ID	6750
PDB ID	1P2W
Drugpedia	wiki
Comments

Search Result - 78

HMRbase accession number	11506
Swiss-prot Accession number	Q86YW7 (Sequence in FASTA format)
Description	Glycoprotein hormone beta-5 precursor (Thyrostimulin subunit beta).
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted protein
Developmental Stage	N/A
Similarity	Belongs to the glycoprotein hormones subunit beta family.
Tissue Specificity	Highly expressed in brain and at low levels in pituitary. Also found in retina, testis and skin but not in pancreas, parotid, kidney, stomach, liver, colon, small intestine, thyroid, brain or adrenal gland. In pituitary, colocalizes with ACTH, suggesting that it is located in corticotrophs
Post translational modification	N-glycosylated.
Function	Stimulates the thyroid. Binds and activates THSR, leading to increased cAMP production
Protein Length	130 Amino acids
Molecular weight	14232
References	1  PubMed abstract 12045258 2   Holloway J.L., O'Hogan S.L., Tackett M., Taft D., Thayer E.C.,Webster P.; "A novel glycoprotein hormone beta subunit."; Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases. 3  PubMed abstract 12508121 4  PubMed abstract 15489334 5  PubMed abstract 12089349 6  PubMed abstract 16210345
Domain Name	Cys_knot
Hormone Name	Glycoprotein hormone beta-5
Mature Hormone Sequence	ASSGNLRTFVGCAVREFTFLAKKPGCRGLRITTDACWGRCETWEKPILEPPYIEAHHRVCTYNETKQVTVKLPNCAPGVDPFYTYPVAIRCDCGACSTATTECETI
Position of mature hormone in Pre-Hormone protein	106 Residues from position (25-130)
Receptor	P16473    Detail in HMRbase
Gene ID	122876
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 79

HMRbase accession number	11531
Swiss-prot Accession number	P41159 (Sequence in FASTA format)
Description	Leptin;Alternative Name: Obesity factor;Alternative Name: Obese protein; Precursor
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the leptin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
Protein Length	167 Amino acids
Molecular weight	18641
References	1  PubMed abstract 7984236 2  PubMed abstract 7789654 3  PubMed abstract 8626726 4  PubMed abstract 7499240 5  PubMed abstract 8621021 6  PubMed abstract 15489334 7  PubMed abstract 10428856 8  PubMed abstract 9166907 9  PubMed abstract 9144295 10  PubMed abstract 9500540
Domain Name	Leptin
Hormone Name	Leptin
Mature Hormone Sequence
Position of mature hormone in Pre-Hormone protein
Receptor	P48357   Detail in HMRbase    O95214   Detail in HMRbase    O15243   Detail in HMRbase    A8K2E3   Detail in HMRbase    Q6FHL5   Detail in HMRbase    Q6FHL7   Detail in HMRbase
Gene ID	3952
PDB ID	1AX8
Drugpedia	wiki
Comments

Search Result - 80

HMRbase accession number	11544
Swiss-prot Accession number	A4D0Y8 (Sequence in FASTA format)
Description	Leptin (Obesity homolog, mouse)
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	N/A
Developmental Stage	N/A
Similarity	N/A
Tissue Specificity	N/A
Post translational modification	N/A
Function	N/A
Protein Length	167 Amino acids
Molecular weight	18641
References	1  PubMed abstract 12690205
Domain Name	Leptin
Hormone Name	Leptin
Mature Hormone Sequence
Position of mature hormone in Pre-Hormone protein
Receptor	P48357   Detail in HMRbase    O95214   Detail in HMRbase    O15243   Detail in HMRbase    A8K2E3   Detail in HMRbase    Q6FHL5   Detail in HMRbase    Q6FHL7   Detail in HMRbase
Gene ID	3952
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 81

HMRbase accession number	11545
Swiss-prot Accession number	B2R8Y2 (Sequence in FASTA format)
Description	cDNA, FLJ94114, highly similar to Homo sapiens leptin (obesity homolog, mouse) (LEP), mRNA
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	N/A
Developmental Stage	N/A
Similarity	N/A
Tissue Specificity	N/A
Post translational modification	N/A
Function	N/A
Protein Length	167 Amino acids
Molecular weight	18624
References	----
Domain Name	Leptin
Hormone Name	Leptin
Mature Hormone Sequence
Position of mature hormone in Pre-Hormone protein
Receptor	P48357   Detail in HMRbase    O95214   Detail in HMRbase    O15243   Detail in HMRbase    A8K2E3   Detail in HMRbase    Q6FHL5   Detail in HMRbase    Q6FHL7   Detail in HMRbase
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 82

HMRbase accession number	11546
Swiss-prot Accession number	Q6NT58 (Sequence in FASTA format)
Description	Leptin
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	N/A
Developmental Stage	N/A
Similarity	N/A
Tissue Specificity	N/A
Post translational modification	N/A
Function	N/A
Protein Length	167 Amino acids
Molecular weight	18613
References	1  PubMed abstract 15489334
Domain Name	Leptin
Hormone Name	Leptin
Mature Hormone Sequence
Position of mature hormone in Pre-Hormone protein
Receptor	P48357   Detail in HMRbase    O95214   Detail in HMRbase    O15243   Detail in HMRbase    A8K2E3   Detail in HMRbase    Q6FHL5   Detail in HMRbase    Q6FHL7   Detail in HMRbase
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 83

HMRbase accession number	11575
Swiss-prot Accession number	P00797 (Sequence in FASTA format)
Description	Renin; EC=3.4.23.15;Alternative Name: Angiotensinogenase;Precursor
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2
Developmental Stage	N/A
Similarity	Belongs to the peptidase A1 family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Protein Length	406 Amino acids
Molecular weight	45057
References	1  PubMed abstract 6324167 2  PubMed abstract 3530608 3  PubMed abstract 6391881 4  PubMed abstract 16710414 5  PubMed abstract 15489334 6  PubMed abstract 6138751 7  PubMed abstract 3032746 8  PubMed abstract 2540188 9  PubMed abstract 3516796 10  PubMed abstract 2016271 11  PubMed abstract 12045255 12  PubMed abstract 2493678 13  PubMed abstract 1608447 14  PubMed abstract 16116425
Domain Name	A1_Propeptide  Asp
Hormone Name	Renin
Mature Hormone Sequence
Position of mature hormone in Pre-Hormone protein
Receptor	O75787   Detail in HMRbase
Gene ID	5972
PDB ID	1BBS   1BIL   1BIM   1HRN   1RNE   2BKS   2BKT   2FS4   2G1N   2G1O   2G1R   2G1S   2G1Y   2G20   2G21   2G22   2G24   2G26   2G27   2I4Q   2IKO   2IKU   2IL2   2REN   2V0Z   2V10   2V11   2V12   2V13   2V16   3D91
Drugpedia	wiki
Comments

Search Result - 84

HMRbase accession number	11581
Swiss-prot Accession number	Q6FI38 (Sequence in FASTA format)
Description	REN protein;Renin
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	N/A
Developmental Stage	N/A
Similarity	Belongs to the peptidase A1 family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	N/A
Protein Length	406 Amino acids
Molecular weight	45057
References	----
Domain Name	A1_Propeptide  Asp
Hormone Name	Renin
Mature Hormone Sequence
Position of mature hormone in Pre-Hormone protein
Receptor	O75787   Detail in HMRbase
Gene ID	5972
PDB ID	N/A
Drugpedia	wiki
Comments